Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/4689
Título: | Modification upon aging of the density of presynaptic modulation systems in the hippocampus | Autor: | Canas, Paula M. Duarte, João M. N. Rodrigues, Ricardo J. Köfalvi, Attila Cunha, Rodrigo A. |
Palavras-chave: | Nerve terminals; Density; Adenosine; Metabotropic; Glutamate; Acetylcholine; Synaptophysin | Data: | 1-Set-2008 | Citação: | Neurobiology of Aging. In Press, Corrected Proof: | Resumo: | Different presynaptic neuromodulation systems have been explored as possible targets to manage neurodegenerative diseases. However, most studies used young adult animals whereas neurodegenerative diseases are prevalent in the elderly. Thus, we now explored by Western blot analysis how the density of different presynaptic markers and receptors changes with aging in rat hippocampal synaptosomes (purified nerve terminals). Compared to synaptosomal membranes from 2-month-old rats, the density of presynaptic proteins (synaptophysin or SNAP-25) decreased at 18-24 months. In parallel, markers of glutamatergic terminals (vGluT1 or vGluT2) and cholinergic terminal markers (vAChT) constantly decreased with aging from 12 to 18 months onwards, whereas the densities of GABAergic (vGAT) only decreased after 24 months. Inhibitory A1 and CB1 receptor density tended to decrease with aging, whereas facilitatory mGluR5 and P2Y1 receptor density was roughly constant and facilitatory A2A receptor density increased at 18-24 months. Thus aging causes an imbalance of excitatory versus inhibitory nerve terminal markers and causes a predominant decrease of inhibitory rather than facilitatory presynaptic modulation systems. | URI: | https://hdl.handle.net/10316/4689 | DOI: | 10.1016/j.neurobiolaging.2008.01.003 | Direitos: | openAccess |
Aparece nas coleções: | FMUC Medicina - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
file4596e52bbb4545fc83e77ba15800125a.pdf | 574.38 kB | Adobe PDF | Ver/Abrir |
Citações SCOPUSTM
108
Visto em 15/abr/2024
Citações WEB OF SCIENCETM
103
Visto em 2/abr/2024
Visualizações de página 50
529
Visto em 16/abr/2024
Downloads
620
Visto em 16/abr/2024
Google ScholarTM
Verificar
Altmetric
Altmetric
Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.