Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/45373
Title: | The influence of atherosclerotic plaques on the pharmacokinetics of a drug eluted from bioabsorbable stents | Authors: | Ferreira, José Augusto Gonçalves, Lino Naghipoor, Jahed Oliveira, Paula de Rabczuk, Timon |
Keywords: | Absorbable Implants; Antineoplastic Agents; Arteries; Paclitaxel; Plaque, Atherosclerotic; Sirolimus; Drug-Eluting Stents; Models, Theoretical | Issue Date: | 2017 | Publisher: | Elsevier | Project: | info:eu-repo/grantAgreement/FCT/5876/147205/PT | Serial title, monograph or event: | Mathematical Biosciences | Volume: | 283 | Abstract: | In this paper the effect of plaque composition, on the accumulation of drug released by a drug eluting stent, is analyzed. The mathematical model is represented by two coupled systems of partial differential equations that describe the pharmacokinetics of drug in the stent coating and in the arterial wall. The influence of the stiffness and porosity of soft and hard plaques is studied. A case study based on optical coherence tomography images is also included. | URI: | https://hdl.handle.net/10316/45373 | DOI: | 10.1016/j.mbs.2016.11.005 10.1016/j.mbs.2016.11.005 |
Rights: | embargoedAccess |
Appears in Collections: | I&D CMUC - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
PAPER2pdf.pdf | 3.85 MB | Adobe PDF | View/Open |
SCOPUSTM
Citations
14
checked on Nov 9, 2022
WEB OF SCIENCETM
Citations
10
16
checked on Mar 2, 2024
Page view(s) 10
1,012
checked on Mar 26, 2024
Download(s)
316
checked on Mar 26, 2024
Google ScholarTM
Check
Altmetric
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.