Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/45140
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dc.contributor.authorMilhazes, Nuno-
dc.contributor.authorCalheiros, Rita-
dc.contributor.authorMarques, M. Paula M.-
dc.contributor.authorGarrido, Jorge-
dc.contributor.authorCordeiro, M. Natália D. S.-
dc.contributor.authorRodrigues, Cátia-
dc.contributor.authorQuinteira, Sandra-
dc.contributor.authorNovais, Carla-
dc.contributor.authorPeixe, Luísa-
dc.contributor.authorBorges, Fernanda-
dc.date.accessioned2017-12-15T18:41:01Z-
dc.date.available2017-12-15T18:41:01Z-
dc.date.issued2006-
dc.identifier.urihttp://hdl.handle.net/10316/45140-
dc.description.abstractA multidisciplinary project was developed, combining the synthesis of a series of beta-nitrostyrene derivatives and the determination of their physicochemical parameters (redox potentials, partition coefficients), to the evaluation of the corresponding antibacterial activity. A complete conformational analysis was also performed, in order to get relevant structural information. Subsequently, a structure-property-activity (SPAR) approach was applied, through linear regression analysis, aiming at obtaining a putative correlation between the physicochemical parameters of the compounds investigated and their antibacterial activity (both against standard strains and clinical isolates). The beta-nitrostyrene compounds displayed a lower activity towards all the tested bacteria relative to the beta-methyl-beta-nitrostyrene analogues. This was observed particularly for the 3-hydroxy-4-methoxy-beta-methyl-beta-nitrostyrene (IVb) against the Gram-positive bacteria (Staphylococcus aureus, Enterococcus faecalis and Enterococcus faecium). The SPAR results revealed the existence of a clear correlation between the redox potentials and the antibacterial activity of the series of beta-nitrostyrene derivatives under study.por
dc.language.isoengpor
dc.rightsopenAccesspor
dc.subjectAnti-Bacterial Agentspor
dc.subjectElectrochemistrypor
dc.subjectGram-Positive Bacteriapor
dc.subjectMicrobial Sensitivity Testspor
dc.subjectModels, Molecularpor
dc.subjectMolecular Structurepor
dc.subjectOxidation-Reductionpor
dc.subjectStructure-Activity Relationshippor
dc.subjectStyrenespor
dc.titleβ-Nitrostyrene derivatives as potential antibacterial agents: A structure–property–activity relationship studypor
dc.typearticle-
degois.publication.firstPage4078por
degois.publication.lastPage4088por
degois.publication.issue12por
degois.publication.titleBioorganic & Medicinal Chemistrypor
dc.peerreviewedyespor
dc.identifier.doi10.1016/j.bmc.2006.02.006por
dc.identifier.doi10.1016/j.bmc.2006.02.006-
degois.publication.volume14por
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.languageiso639-1en-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitQFM-UC – Molecular Physical-Chemistry R&D Unit-
crisitem.author.orcid0000-0002-8391-0055-
crisitem.author.orcid0000-0001-8981-231X-
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
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