Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/45137
Title: Drug–excipient interactions in ketoprofen: A vibrational spectroscopy study
Authors: de Carvalho, L. A. E. Batista 
Marques, M. Paula M. 
Tomkinson, John 
Keywords: Anti-Inflammatory Agents, Non-Steroidal; Elasticity; Excipients; Ketoprofen; Lactose; Neutron Diffraction; Povidone; Spectrum Analysis, Raman
Issue Date: 2006
Serial title, monograph or event: Biopolymers
Volume: 82
Issue: 4
Abstract: Ketoprofen (3-benzoyl-alpha-methylbenzeneacetic acid) is a widely used nonsteroidal anti-inflammatory drug (NSAID), always administered in the form of drug-excipient physical mixtures (PMs). The occurrence of possible interactions between ketoprofen and two commonly used excipients-lactose (LAC) and polyvinylpyrrolidone (PVP)-was evaluated, through vibrational spectroscopy techniques [both Raman and Inelastic Neutron Scattering (INS)]. Spectral evidence of drug:excipient close contacts, which were enhanced by aging, was verified for the (1:1) (w:w) (ketoprofen:PVP) and (ketoprofen:LAC) PMs, both by Raman and INS. These interactions were found to involve mainly the central carbonyl and the terminal methyl-carboxylic moieties of the ketoprofen molecule, this being reflected in particular vibrational modes, such as the methyl torsion, the out-of-plane C-OH bending, and the inter-ring C=O stretching.
URI: http://hdl.handle.net/10316/45137
Other Identifiers: 10.1002/bip.20517
DOI: 10.1002/bip.20517
Rights: openAccess
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais

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