Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/45121
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dc.contributor.authorEsteves, Mário-
dc.contributor.authorSiquet, Christophe-
dc.contributor.authorGaspar, Alexandra-
dc.contributor.authorRio, Vitor-
dc.contributor.authorSousa, Joana B.-
dc.contributor.authorReis, Salette-
dc.contributor.authorMarques, Maria P. M.-
dc.contributor.authorBorges, Fernanda-
dc.date.accessioned2017-12-15T18:18:50Z-
dc.date.available2017-12-15T18:18:50Z-
dc.date.issued2008-
dc.identifier.urihttp://hdl.handle.net/10316/45121-
dc.description.abstractTrihydroxycinnamic derivatives were synthesized and evaluated for their antioxidant and cytotoxic activities. The ester derivatives exhibited a higher radical-scavenging activity, when liposomes were used as target systems, a fact which may be related to their lipophilicity and conformational preferences. These compounds were found to display significant growth inhibition and cytotoxic effects towards a human cervix adenocarcinoma cell line (HeLa). The partition coefficients presently obtained for the trihydroxycinnamic derivatives correlate well both with their structural characteristics and with their antioxidant/cytotoxic activities. A positive structure-activity-property relationship between cytotoxic and antioxidant activities, which is intrinsically related with physico-chemical and conformational properties, is anticipated, as a noteworthy study that must be done for phenolic systems. As damage events are frequently correlated with oxidative stress, the prevalence of both properties in a single compound could be beneficial in terms of rationale preventive or therapeutic purposes.por
dc.language.isoengpor
dc.rightsopenAccesspor
dc.subjectAntineoplastic Agentspor
dc.subjectCoumaric Acidspor
dc.subjectFemalepor
dc.subjectFree Radical Scavengerspor
dc.subjectFree Radicalspor
dc.subjectHeLa Cellspor
dc.subjectHumanspor
dc.subjectHydrophobic and Hydrophilic Interactionspor
dc.subjectLiposomespor
dc.subjectOxidative Stresspor
dc.subjectStructure-Activity Relationshippor
dc.subjectUterine Cervical Neoplasmspor
dc.titleAntioxidant Versus Cytotoxic Properties of Hydroxycinnamic Acid Derivatives – A New Paradigm in Phenolic Researchpor
dc.typearticle-
degois.publication.firstPage164por
degois.publication.lastPage173por
degois.publication.issue3por
degois.publication.titleArchiv der Pharmaziepor
dc.peerreviewedyespor
dc.identifier.doi10.1002/ardp.200700168por
dc.identifier.doi10.1002/ardp.200700168-
degois.publication.volume341por
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.languageiso639-1en-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitQFM-UC – Molecular Physical-Chemistry R&D Unit-
crisitem.author.orcid0000-0002-8391-0055-
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
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