Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/45121
Title: Antioxidant Versus Cytotoxic Properties of Hydroxycinnamic Acid Derivatives – A New Paradigm in Phenolic Research
Authors: Esteves, Mário 
Siquet, Christophe 
Gaspar, Alexandra 
Rio, Vitor 
Sousa, Joana B. 
Reis, Salette 
Marques, Maria P. M. 
Borges, Fernanda 
Keywords: Antineoplastic Agents; Coumaric Acids; Female; Free Radical Scavengers; Free Radicals; HeLa Cells; Humans; Hydrophobic and Hydrophilic Interactions; Liposomes; Oxidative Stress; Structure-Activity Relationship; Uterine Cervical Neoplasms
Issue Date: 2008
Serial title, monograph or event: Archiv der Pharmazie
Volume: 341
Issue: 3
Abstract: Trihydroxycinnamic derivatives were synthesized and evaluated for their antioxidant and cytotoxic activities. The ester derivatives exhibited a higher radical-scavenging activity, when liposomes were used as target systems, a fact which may be related to their lipophilicity and conformational preferences. These compounds were found to display significant growth inhibition and cytotoxic effects towards a human cervix adenocarcinoma cell line (HeLa). The partition coefficients presently obtained for the trihydroxycinnamic derivatives correlate well both with their structural characteristics and with their antioxidant/cytotoxic activities. A positive structure-activity-property relationship between cytotoxic and antioxidant activities, which is intrinsically related with physico-chemical and conformational properties, is anticipated, as a noteworthy study that must be done for phenolic systems. As damage events are frequently correlated with oxidative stress, the prevalence of both properties in a single compound could be beneficial in terms of rationale preventive or therapeutic purposes.
URI: http://hdl.handle.net/10316/45121
DOI: 10.1002/ardp.200700168
10.1002/ardp.200700168
Rights: openAccess
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais

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