Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/3905
Título: | Potentiometric and NMR spectroscopic study of protonations and amide hydrogen exchange rates of DTPA-bis(butylamide), DTPA-bis(glucamide), and their lanthanide(III) complexes | Autor: | Lammers, Hendrik van der Heijden, Anna M. van Bekkum, Herman Geraldes, Carlos F. G. C. Peters, Joop A. |
Palavras-chave: | MRI contrast agents; Lanthanide complexes | Data: | 1998 | Citação: | Inorganica Chimica Acta. 277:2 (1998) 193-201 | Resumo: | The macroscopic and microscopic protonations of DTPA-GlucA2 (DTPA-bis(glucamide)) have been investigated using potentiometry, 1H and 13C NMR. The protonation behavior appears to be similar to that of the corresponding bis(alkylamides), showing that it is not affected by the presence of the polyhydroxy side chains. Consideration of the various possible protonation pathways leads to the conclusion that the differences in basicity of the amino functions in DTPA and DTPA-bis(amides) result in different protonation sequences of these ligands, which is reflected in the macroscopic protonation constants. The significance for the design of DTPA-based contrast agents for MRI is discussed. Exchange rates of the amide NH of this compound and that of DTPA-bis(butylamide) (DTPA-BuA2) were determined via longitudinal relaxation rate measurements of the amide 1H resonances in H2O---D2O (9:1) as solvent. The reaction is strongly base catalyzed and the rate increases substantially upon coordination of the DTPA-bis(amide) by La(III). | URI: | https://hdl.handle.net/10316/3905 | DOI: | 10.1016/S0020-1693(97)06151-3 | Direitos: | openAccess |
Aparece nas coleções: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
file0e3030e76ec74ee8a7167a38e82c3064.pdf | 1.34 MB | Adobe PDF | Ver/Abrir |
Citações SCOPUSTM
10
Visto em 11/nov/2022
Citações WEB OF SCIENCETM
9
Visto em 2/mai/2023
Visualizações de página
293
Visto em 23/abr/2024
Downloads
264
Visto em 23/abr/2024
Google ScholarTM
Verificar
Altmetric
Altmetric
Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.