Title: Does progesterone administration in preterm labor influence Treg cells?
Authors: Areia, Ana Luísa 
Vale-Pereira, Sofia 
Vaz-Ambrósio, Ana 
Alves, Vera 
Rodrigues-Santos, Paulo 
Rosa, Manuel Santos 
Moura, Paulo 
Mota-Pinto, Anabela 
Keywords: Pregnancy;Preterm labor;Progesterone;Treggs
Issue Date: 2016
Abstract: Objectives: The aim of this study was to determine if the actions of progesterone on preterm labor are accomplished through modulation of the percentage of regulatory T-cells (Treg). Methods: The study was a cohort pilot study made in a single center tertiary obstetrical unit with women in preterm labor arrested with tocolytic treatment. Variation of the number and percentage of Treg cells obtained from peripheral blood samples of women with preterm labor were calculated by flow cytometry, before and after progesterone administration. Results: In the paired samples for each patient, there was a significant difference in the Treg cell pool after progesterone treatment, with an increase in both their percentage (48.9 vs. 53; P = 0.07) and absolute number (14.8 vs. 56.5 cells/μL; P = 0.046). Conclusions: This research demonstrated a considerable increase in the Treg cell pool after progesterone treatment. This indicates a possible mechanism for progesterone treatment benefits in preterm labor, potentially increasing its more rational use.
URI: http://hdl.handle.net/10316/36887
Other Identifiers: 10.1515/jpm-2015-0134
DOI: 10.1515/jpm-2015-0134
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais

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