Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/2804
DC FieldValueLanguage
dc.contributor.authorCastel-Branco, Margarida-
dc.contributor.authorLebre, Vera-
dc.contributor.authorFalcão, Amílcar-
dc.contributor.authorFigueiredo, Isabel-
dc.contributor.authorCaramona, Margarida-
dc.date.accessioned2008-07-10T14:29:46Z-
dc.date.available2008-07-10T14:29:46Z-
dc.date.issued2003-09-30-
dc.identifier.citationEuropean Journal of Pharmacology. 482 (2003) 163-168-
dc.identifier.issn0014-2999pt
dc.identifier.urihttps://hdl.handle.net/10316/2804-
dc.description.abstractThe aims of the present research were to characterize the plasma and brain concentration–time profiles of lamotrigine after its acute administration and to establish the relationship between these profiles and the anticonvulsant effect of lamotrigine in rats. Adult male Wistar rats were given 10 mg/kg of lamotrigine intraperitoneally. The lamotrigine profiles in plasma and brain were determined at predetermined times over 120-h post-dose. The anticonvulsant profile against maximal electroshock seizure stimulation was determined over 48 h after dosing. After injection, lamotrigine rapidly appeared in both plasma and brain, suggesting ready penetration of the blood–brain barrier. A linear relationship was established between lamotrigine plasma and brain levels. A linear relationship was also defined between lamotrigine brain levels and the anticonvulsant response. The correspondent plasma levels were also well correlated with the anticonvulsant effect from the moment that the plasma–brain system had reached equilibrium.pt
dc.format.mimetypeaplication/PDF-
dc.language.isoengpt
dc.publisherElsevierpt
dc.relationinfo:eu-repo/grantAgreement/FCT/POCTI/PRAXIS XXI/BD/18351/98/PT/CARACTERIZAÇÃO DO PERFIL NEUROFARMACOCINÉTICO DA LAMOTRIGINA EM RATOS MEDIANTE A UTILIZAÇÃO DE MICRO- DIÁLISEpt
dc.rightsopenAccesspt
dc.subjectLamotriginept
dc.subjectAnticonvulsantpt
dc.subjectElectroshockpt
dc.subjectPharmacokineticspt
dc.subjectPharmacodynamicspt
dc.titleRelationship between plasma and brain levels and the anticonvulsant effect of lamotrigine in ratspt
dc.typearticle-
degois.publication.firstPage163pt
degois.publication.lastPage168pt
degois.publication.issue1-3pt
degois.publication.titleEuropean Journal of Pharmacologypt
dc.date.updated2022-07-30T22:03:28Z-
dc.peerreviewedyespt
dc.identifier.doi10.1016/j.ejphar.2003.09.065pt
degois.publication.volume482pt
dc.description.version3910-3178-31BA | MARIA MARGARIDA COUTINHO DE SEABRA CASTEL-BRANCO CAETANO-
dc.description.versionN/A-
dc.date.embargo2003-09-30*
uc.date.periodoEmbargo0pt
item.openairetypearticle-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.fulltextCom Texto completo-
crisitem.author.researchunitICBR Coimbra Institute for Clinical and Biomedical Research-
crisitem.author.parentresearchunitFaculty of Medicine-
crisitem.author.orcid0000-0002-6533-9932-
crisitem.author.orcid0000-0002-3854-6549-
crisitem.author.orcid0000-0003-1950-9360-
Appears in Collections:FFUC- Artigos em Revistas Internacionais
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