Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/27767
Title: Triazole-linked phenyl derivatives: redox mechanisms and in situ electrochemical evaluation of interaction with dsDNA
Authors: Pontinha, A. Dora R. 
Lombardo, Caterina M. 
Neidle, Stephen 
Brett, Ana Maria Oliveira 
Keywords: Substituted triazole-linked phenyl compounds; dsDNA electrochemical biosensor; Voltammetry; Glassy carbon electrode
Issue Date: Feb-2015
Publisher: Elsevier
Citation: PONTINHA, A. Dora R. [et. al] - Triazole-linked phenyl derivatives: redox mechanisms and in situ electrochemical evaluation of interaction with dsDNA. "Bioelectrochemistry". ISSN 1567-5394. Vol. 101 (2015) p. 97–105
Serial title, monograph or event: Bioelectrochemistry
Volume: 101
Abstract: The redox mechanism of two trisubstituted triazole-linked phenyl derivatives (CL41 and CL42) and a disubstituted triazole-linked phenyl derivative (CL2r50) were studied using cyclic, differential pulse and square wave voltammetry at a glassy carbon electrode. The CL41, CL42 and CL2r50 oxidation is a complex, pH-dependent irreversible process involving the formation of electroactive products that undergo two consecutive reversible oxidation reactions. The DNA interaction with CL41, CL42 and CL2r50 was investigated by differential pulse voltammetry using the dsDNA-electrochemical biosensor and in DNA/trisubstituted triazole incubated solutions. All three trisubstituted triazole-linked phenyl derivatives interacted with dsDNA causing morphological and oxidative damage to the dsDNA structure in a time-dependent manner. The DNA-electrochemical biosensor enabled the detection of oxidative damage to DNA following the occurrence of the 8-oxoGua and/or 2,8-oxoAde oxidation peaks.
URI: https://hdl.handle.net/10316/27767
ISSN: 1567-5394
DOI: 10.1016/j.bioelechem.2014.08.010
Rights: openAccess
Appears in Collections:FCTUC Química - Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat
Triazole-linked phenyl derivatives.pdf467.51 kBAdobe PDFView/Open
Show full item record

SCOPUSTM   
Citations

2
checked on Mar 18, 2024

WEB OF SCIENCETM
Citations 10

2
checked on Mar 2, 2024

Page view(s)

282
checked on Mar 26, 2024

Download(s) 50

426
checked on Mar 26, 2024

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.