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Title: Triazole-linked phenyl derivatives: redox mechanisms and in situ electrochemical evaluation of interaction with dsDNA
Authors: Pontinha, A. Dora R. 
Lombardo, Caterina M. 
Neidle, Stephen 
Brett, Ana Maria Oliveira 
Keywords: Substituted triazole-linked phenyl compounds; dsDNA electrochemical biosensor; Voltammetry; Glassy carbon electrode
Issue Date: Feb-2015
Publisher: Elsevier
Citation: PONTINHA, A. Dora R. [et. al] - Triazole-linked phenyl derivatives: redox mechanisms and in situ electrochemical evaluation of interaction with dsDNA. "Bioelectrochemistry". ISSN 1567-5394. Vol. 101 (2015) p. 97–105
Serial title, monograph or event: Bioelectrochemistry
Volume: 101
Abstract: The redox mechanism of two trisubstituted triazole-linked phenyl derivatives (CL41 and CL42) and a disubstituted triazole-linked phenyl derivative (CL2r50) were studied using cyclic, differential pulse and square wave voltammetry at a glassy carbon electrode. The CL41, CL42 and CL2r50 oxidation is a complex, pH-dependent irreversible process involving the formation of electroactive products that undergo two consecutive reversible oxidation reactions. The DNA interaction with CL41, CL42 and CL2r50 was investigated by differential pulse voltammetry using the dsDNA-electrochemical biosensor and in DNA/trisubstituted triazole incubated solutions. All three trisubstituted triazole-linked phenyl derivatives interacted with dsDNA causing morphological and oxidative damage to the dsDNA structure in a time-dependent manner. The DNA-electrochemical biosensor enabled the detection of oxidative damage to DNA following the occurrence of the 8-oxoGua and/or 2,8-oxoAde oxidation peaks.
ISSN: 1567-5394
DOI: 10.1016/j.bioelechem.2014.08.010
Rights: openAccess
Appears in Collections:FCTUC Química - Artigos em Revistas Internacionais

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