Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/27408
DC FieldValueLanguage
dc.contributor.authorAlmeida, Otília C. d'-
dc.contributor.authorMateus, Catarina-
dc.contributor.authorReis, Aldina-
dc.contributor.authorGrazina, Manuela M.-
dc.contributor.authorCastelo-Branco, Miguel-
dc.date.accessioned2014-10-28T14:03:35Z-
dc.date.available2014-10-28T14:03:35Z-
dc.date.issued2013-11-01-
dc.identifier.citationd'ALMEIDA, Otília C. [et. al] - Long term cortical plasticity in visual retinotopic areas in humans with silent retinal ganglion cell loss. "NeuroImage". ISSN 1053-8119. Vol. 81 (2013) p. 222-230por
dc.identifier.issn1053-8119-
dc.identifier.urihttp://hdl.handle.net/10316/27408-
dc.description.abstractVisual cortical plasticity induced by overt retinal lesions (scotomas) has remained a controversial phenomenon. Here we studied cortical plasticity in a silent model of retinal ganglion cell loss, documented by in vivo optical biopsy using coherence tomography. The cortical impact of non-scotomatous subtle retinal ganglion cell functional and structural loss was investigated in carriers of the mitochondrial DNA 11778G > A mutation causing Leber's hereditary optic neuropathy. We used magnetic resonance imaging (MRI) to measure cortical thickness and fMRI to define retinotopic cortical visual areas V1, V2 and V3 in silent carriers and matched control groups. Repeated Measures analysis of variance revealed a surprising increase in cortical thickness in the younger carrier group (below 21 years of age). This effect dominated in extrastriate cortex, and notably V2. This form of structural plasticity suggests enhanced plastic developmental mechanisms in extrastriate retinotopic regions close to V1 and not receiving direct retinocortical input.por
dc.language.isoengpor
dc.publisherElsevierpor
dc.rightsopenAccesspor
dc.subjectCortical plasticitypor
dc.subjectVisual losspor
dc.subjectRetinotopic visual areaspor
dc.subjectGanglion cellspor
dc.subjectDevelopmentpor
dc.subjectMitochondrial gene mutationspor
dc.titleLong term cortical plasticity in visual retinotopic areas in humans with silent retinal ganglion cell losspor
dc.typearticlepor
degois.publication.firstPage222por
degois.publication.lastPage230por
degois.publication.titleNeuroImagepor
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S1053811913005260por
dc.peerreviewedYespor
dc.identifier.doi10.1016/j.neuroimage.2013.05.032-
degois.publication.volume81por
uc.controloAutoridadeSim-
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.languageiso639-1en-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCIBIT - Coimbra Institute for Biomedical Imaging and Translational Research-
crisitem.author.orcid0000-0003-4849-0507-
crisitem.author.orcid0000-0001-7598-8736-
crisitem.author.orcid0000-0002-1173-6481-
crisitem.author.orcid0000-0003-4364-6373-
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais
I&D IBILI - Artigos em Revistas Internacionais
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