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Title: Plasmid DNA hydrogels for biomedical applications
Authors: Costa, Diana 
Valente, Artur J. M. 
Miguel, M. Graça 
Queiroz, João 
Keywords: Plasmid DNA microgels; Biocompatibility; pDNA delivery; Drug delivery; Co-delivery; In-vitro transfection
Issue Date: Mar-2014
Publisher: Elsevier
Citation: COSTA, Diana [et al.] - Plasmid DNA hydrogels for biomedical applications. "Advances in Colloid and Interface Science". ISSN 0001-8686. Vol. 205 (2014) p. 257-264
Serial title, monograph or event: Advances in Colloid and Interface Science
Volume: 205
Abstract: In the last few years, our research group has focused on the design and development of plasmid DNA (pDNA) based systems as devices to be used therapeutically in the biomedical field. Biocompatible macro and micro plasmid DNA gels were prepared by a cross-linking reaction. For the first time, the pDNA gels have been investigated with respect to their swelling in aqueous solution containing different additives. Furthermore, we clarified the fundamental and basic aspects of the solute release mechanism from pDNA hydrogels and the significance of this information is enormous as a basic tool for the formulation of pDNA carriers for drug/gene delivery applications. The co-delivery of a specific gene and anticancer drugs, combining chemical and gene therapies in the treatment of cancer was the main challenge of our research. Significant progresses have been made with a new p53 encoding pDNA microgel that is suitable for the loading and release of pDNA and doxorubicin. This represents a strong valuable finding in the strategic development of systems to improve cancer cure through the synergetic effect of chemical and gene therapy.
ISSN: 0001-8686
DOI: 10.1016/j.cis.2013.08.002
Rights: openAccess
Appears in Collections:FCTUC Química - Artigos em Revistas Internacionais

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