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Title: Dysfunctional synapse in Alzheimer’s disease – a focus on NMDA receptors
Authors: Mota, Sandra I. 
Ferreira, Ildete L. 
Rego, A. Cristina 
Keywords: Alzheimer's disease; Amyloid-beta peptide; Synaptic dysfunction; NMDA receptors; GluN2A and GluN2B subunits; Tripartite synapse
Issue Date: Jan-2014
Publisher: Elsevier
Citation: MOTA, Sandra I. ; FERREIRA, Iidete L. ; REGO, A. Cristina - Dysfunctional synapse in Alzheimer's disease – A focus on NMDA receptors. "Neuropharmacology". ISSN 0028-3908. Vol. 76 (2014) p. 16-26
Serial title, monograph or event: Neuropharmacology
Volume: 76
Abstract: Alzheimer's disease (AD) is the most prevalent form of dementia in the elderly. Alterations capable of causing brain circuitry dysfunctions in AD may take several years to develop. Oligomeric amyloid-beta peptide (Aβ) plays a complex role in the molecular events that lead to progressive loss of function and eventually to neurodegeneration in this devastating disease. Moreover, N-methyl-d-aspartate (NMDA) receptors (NMDARs) activation has been recently implicated in AD-related synaptic dysfunction. Thus, in this review we focus on glutamatergic neurotransmission impairment and the changes in NMDAR regulation in AD, following the description on the role and location of NMDARs at pre- and post-synaptic sites under physiological conditions. In addition, considering that there is currently no effective ways to cure AD or stop its progression, we further discuss the relevance of NMDARs antagonists to prevent AD symptomatology. This review posits additional information on the role played by Aβ in AD and the importance of targeting the tripartite glutamatergic synapse in early asymptomatic and possible reversible stages of the disease through preventive and/or disease-modifying therapeutic strategies. This article is part of the Special Issue entitled ‘The Synaptic Basis of Neurodegenerative Disorders’.
ISSN: 0028-3908
DOI: 10.1016/j.neuropharm.2013.08.013
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais

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