Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/26841
Title: Synergistic impact of endurance training and intermittent hypobaric hypoxia on cardiac function and mitochondrial energetic and signaling
Authors: Magalhães, J. 
Falcão-Pires, I. 
Gonçalves, I. O. 
Lumini-Oliveira, J. 
Marques-Aleixo, I. 
Passos, E. dos 
Rocha-Rodrigues, S. 
Machado, N. G. 
Moreira, A. C. 
Miranda-Silva, D. 
Moura, C. 
Leite-Moreira, A. F. 
Oliveira, P. J. 
Torrella, J. R. 
Ascensão, A. 
Keywords: Physical exercise; Altitude; Cardioprotection; Bioenergetics
Issue Date: 15-Oct-2013
Publisher: Elsevier
Citation: MAGALHÃES, J. [et al.] - Synergistic impact of endurance training and intermittent hypobaric hypoxia on cardiac function and mitochondrial energetic and signaling. "International Journal of Cardiology". ISSN 0167-5273. Vol. 168 Nº. 6 (2013) p. 5363–5371
Serial title, monograph or event: International Journal of Cardiology
Volume: 168
Issue: 6
Abstract: Background Intermittent hypobaric-hypoxia (IHH) and endurance-training (ET) are cardioprotective strategies against stress-stimuli. Mitochondrial modulation appears to be an important step of the process. This study aimed to analyze whether a combination of these approaches provides additive or synergistic effects improving heart-mitochondrial and cardiac-function. Methods Two-sets of rats were divided into normoxic-sedentary (NS), normoxic-exercised (NE, 1 h/day/5 weeks treadmill-running), hypoxic-sedentary (HS, 6000 m, 5 h/day/5 weeks) and hypoxic-exercised (HE) to study overall cardiac and mitochondrial function. In vitro cardiac mitochondrial oxygen consumption and transmembrane potential were evaluated. OXPHOS subunits and ANT protein content were semi-quantified by Western blotting. HIF-1α, VEGF, VEGF-R1 VEGF-R2, BNP, SERCA2a and PLB expressions were measured by qRT-PCR and cardiac function was characterized by echocardiography and hemodynamic parameters. Results Respiratory control ratio (RCR) increased in NE, HS and HE vs. NS. Susceptibility to anoxia/reoxygenation-induced dysfunction decreased in NE, HS and HE vs. NS. HS decreased mitochondrial complex-I and -II subunits; however HE completely reverted the decreased content in complex-II subunits. ANT increased in HE. HE presented normalized ventricular–arterial coupling (Ea) and BNP myocardial levels and significantly improved myocardial performance as evaluated by increased cardiac output and normalization of the Tei index vs. HS. Conclusion Data demonstrates that IHH and ET confer cardiac mitochondria with a more resistant phenotype although without visible addictive effects at least under basal conditions. It is suggested that the combination of both strategies, although not additive, results into improved cardiac function.
URI: http://hdl.handle.net/10316/26841
ISSN: 0167-5273
DOI: 10.1016/j.ijcard.2013.08.001
Rights: openAccess
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais
FCTUC Ciências da Vida - Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat
Synergistic impact of endurance training.pdf416 kBAdobe PDFView/Open
Show full item record

SCOPUSTM   
Citations

16
checked on Feb 18, 2020

WEB OF SCIENCETM
Citations 5

21
checked on Jan 2, 2022

Page view(s) 5

1,353
checked on Dec 24, 2021

Download(s)

235
checked on Dec 24, 2021

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.