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Title: A poly(ε-caprolactone) device for sustained release of an anti-glaucoma drug
Authors: Natu, Mădălina V. 
Gaspar, Manuel N. 
Ribeiro, Carlos A. Fontes 
Correia, Ilídio J. 
Silva, Daniela 
Sousa, Hermínio C. de 
Gil, M. H. 
Issue Date: 2011
Publisher: IOP Publishing
Citation: NATU, Mădălina V. [et al.] - A poly(ε-caprolactone) device for sustained release of an anti-glaucoma drug. "Biomedical Materials". ISSN 1748-60416. 6:2 (2011) 9 p.
Serial title, monograph or event: Biomedical Materials
Volume: 6
Issue: 2
Abstract: Implantable dorzolamide-loaded discs were prepared by blending poly(ε-caprolactone), PCL, with poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide), Lu. By blending, crystallinity, water uptake and mass loss were modified relative to the pure polymers. Burst was diminished by coating the discs with a PCL shell. All samples presented burst release except PCL-coated samples that showed controlled release during 18 days. For PCL-coated samples, barrier control of diffusion coupled with partition control from the core slowed down the release, while for 50/50 Lu/PCL-coated samples, the enhancement in the porosity of the core diminished partition control of drug release. Nonlinear regression analysis suggested that a degradation model fully describes the release curve considering a triphasic release mechanism: the instantaneous diffusion (burst), diffusion and polymer degradation stages. The MTT test indicated that the materials are not cytotoxic for corneal endothelial cells. A good in vitro–in vivo correlation was obtained, with similar amounts of drug released in vitro and in vivo. The discs decreased intraocular pressure (IOP) in normotensive rabbit eyes by 13.0% during 10 days for PCL-coated and by 13.0% during 4 days for 50/50 Lu/PCL-coated samples. The percentages of IOP decrease are similar to those obtained by dorzolamide eyedrop instillation (11.0%).
ISSN: 1748-6041
DOI: 10.1088/1748-6041/6/2/025003
Rights: closedAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
FCTUC Eng.Química - Artigos em Revistas Internacionais

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