Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/12640
Título: | Enhanced mitochondrial testicular antioxidant capacity in Goto-Kakizaki diabetic rats: role of coenzyme Q | Autor: | Palmeira, Carlos M. Santos, Dario L. Seiça, Raquel Moreno, António J. Santos, Maria S. |
Palavras-chave: | Diabetes mellitus; Sexual dysfunction; Oxidative stress; Testis mitochondria; Glutahione; Vitamin E | Data: | Set-2001 | Editora: | The American Physiological Society | Citação: | American Journal of Physiology, Cell Physiology. 281 (2001) C1023-C1028 | Resumo: | Because diabetes mellitus is associated with impairment of testicular function, ultimately leading to reduced fertility, this study was conducted to evaluate the existence of a cause-effect relationship between increased oxidative stress in diabetes and reduced mitochondrial antioxidant capacity. The susceptibility to oxidative stress and antioxidant capacity (in terms of glutathione, coenzyme Q, and vitamin E content) of testis mitochondrial preparations isolated from Goto-Kakizaki (GK) non-insulin-dependent diabetic rats and from Wistar control rats, 1 yr of age, was evaluated. It was found that GK mitochondrial preparations showed a lower susceptibility to lipid peroxidation induced by ADP/Fe(2+), as evaluated by oxygen consumption and reactive oxygen species generation. The decreased susceptibility to oxidative stress in diabetic rats was associated with an increase in mitochondrial glutathione and coenzyme Q9 contents, whereas vitamin E was not changed. These results demonstrate a higher antioxidant capacity in diabetic GK rats. We suggest this is an adaptive response of testis mitochondria to the increased oxidative damage in diabetes mellitus | URI: | https://hdl.handle.net/10316/12640 | ISSN: | 0363-6143 | DOI: | 10.1152/ajpcell.2001.281.3.c1023 | Direitos: | openAccess |
Aparece nas coleções: | FMUC Medicina - Artigos em Revistas Internacionais FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Enhanced mitochondrial testicular antioxidant capacity.pdf | 195.65 kB | Adobe PDF | Ver/Abrir |
Citações SCOPUSTM
56
Visto em 9/nov/2022
Citações WEB OF SCIENCETM
44
Visto em 2/mai/2023
Visualizações de página
314
Visto em 23/abr/2024
Downloads 5
4.104
Visto em 23/abr/2024
Google ScholarTM
Verificar
Altmetric
Altmetric
Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.