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Title: Antioxidant and vascular effects of gliclazide in type 2 diabetic rats fed high-fat diet
Authors: Sena, C. M. 
Louro, T. 
Matafome, P. 
Nunes, E. 
Monteiro, P. 
Seiça, R. 
Keywords: Endothelium; Nitric Oxide; Diabetes mellitus; Gliclazide; Oxidative stress
Issue Date: Apr-2009
Publisher: Institute of Physiology, Czech Academy of Sciences
Citation: Physiological Research. 58:2 (2009) 203-209
Abstract: Diabetes mellitus is characterized by oxidative stress, which in turn determines endothelial dysfunction. Gliclazide is a sulphonylurea antidiabetic drug with antioxidant effects due to its azabicyclo-octyl ring. It has been reported to potentially protect the vasculature through improvements in plasma lipid levels and platelet function. We hypothesized that gliclazide has a beneficial effect on endothelial function in Goto-Kakizaki rats (GK), an animal model of type 2 diabetes fed an atherogenic diet for 4 months. We evaluated the influence of gliclazide on both metabolic and oxidative status and NO-mediated vasodilation. GKAD rats showed increased oxidative stress and impaired endothelium-dependent vasodilation. GKAD rats treated with gliclazide showed increased sensitivity to NO-mediated vasodilation, a significant decrease in fasting glycemia and insulinemia, and a significant decrease in systemic oxidative stress. In conclusion, our results suggest that gliclazide treatment improves NO-mediated vasodilation in diabetic GK rats with dyslipidemia probably due to its antioxidant effects, although we cannot rule out substantial benefits due to a reduction in fasting blood glucose. The availability of a compound that simultaneously decreases hyperglycemia, hyperinsulinemia, and inhibits oxidative stress is a promising therapeutic candidate for the prevention of vascular complications of diabetes
ISSN: 0862-8408
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais

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