Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/12542
Title: | Antioxidant and vascular effects of gliclazide in type 2 diabetic rats fed high-fat diet | Authors: | Sena, C. M. Louro, T. Matafome, P. Nunes, E. Monteiro, P. Seiça, R. |
Keywords: | Endothelium; Nitric Oxide; Diabetes mellitus; Gliclazide; Oxidative stress | Issue Date: | Apr-2009 | Publisher: | Institute of Physiology, Czech Academy of Sciences | Citation: | Physiological Research. 58:2 (2009) 203-209 | Abstract: | Diabetes mellitus is characterized by oxidative stress, which in turn determines endothelial dysfunction. Gliclazide is a sulphonylurea antidiabetic drug with antioxidant effects due to its azabicyclo-octyl ring. It has been reported to potentially protect the vasculature through improvements in plasma lipid levels and platelet function. We hypothesized that gliclazide has a beneficial effect on endothelial function in Goto-Kakizaki rats (GK), an animal model of type 2 diabetes fed an atherogenic diet for 4 months. We evaluated the influence of gliclazide on both metabolic and oxidative status and NO-mediated vasodilation. GKAD rats showed increased oxidative stress and impaired endothelium-dependent vasodilation. GKAD rats treated with gliclazide showed increased sensitivity to NO-mediated vasodilation, a significant decrease in fasting glycemia and insulinemia, and a significant decrease in systemic oxidative stress. In conclusion, our results suggest that gliclazide treatment improves NO-mediated vasodilation in diabetic GK rats with dyslipidemia probably due to its antioxidant effects, although we cannot rule out substantial benefits due to a reduction in fasting blood glucose. The availability of a compound that simultaneously decreases hyperglycemia, hyperinsulinemia, and inhibits oxidative stress is a promising therapeutic candidate for the prevention of vascular complications of diabetes | URI: | https://hdl.handle.net/10316/12542 | ISSN: | 0862-8408 | Rights: | openAccess |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Antioxidant and vascular effects.pdf | 755.1 kB | Adobe PDF | View/Open |
Page view(s)
359
checked on Oct 29, 2024
Download(s)
172
checked on Oct 29, 2024
Google ScholarTM
Check
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.