Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/11628
Title: A role for atorvastatin and insulin combination in protecting from liver injury in a model of type 2 diabetes with hyperlipidemia
Authors: Matafome, P. 
Nunes, E. 
Louro, T. 
Amaral, C. 
Crisóstomo, J. 
Rodrigues, L. 
Moedas, A. R. 
Monteiro, P. 
Cipriano, A. 
Seiça, R. 
Keywords: Liver; Inflammation; Atorvastatin; Insulin treatment
Issue Date: Mar-2009
Publisher: Springer
Citation: Naunyn-Schmiedeberg's Archives of Pharmacology. 379:3 (2009) 241-251
Abstract: Non-alcoholic fatty liver disease (NAFLD) is a major complication linked with the metabolic syndrome associated with dyslipidemia, inflammation, and oxidative stress. Impact of type 2 diabetes with hyperlipidemia in NAFLD has to be established, as well as the utility of commonly prescribed anti-diabetic and lipid-lowering agents in improving liver injury markers. Genetic type 2 diabetic Goto–Kakizaki rats were fed with a high-fat diet to test hepatic effects of type 2 diabetes with hyperlipidemia and the effect of atorvastatin and insulin, individually and in combination, in systemic and hepatic inflammatory and oxidative stress markers. High-fat diet aggravated fasting glycemia, systemic and liver lipids, and inflammatory and oxidative stress markers. Individual treatments improved glycemic and lipid profiles, but failed to improve inflammatory markers, whereas insulin was able to reduce liver oxidative stress parameters. Combination of insulin and atorvastatin further improved glycemic and lipid profiles and decreased circulating C-reactive protein levels and liver inflammatory and oxidative stress markers. Insulin and atorvastatin combination leads to better glycaemic and lipid profiles and to better protection against liver inflammation and oxidative stress, giving a superior level of liver protection in type 2 diabetic with hyperlipidemia.
URI: https://hdl.handle.net/10316/11628
ISSN: 0028-1298
DOI: 10.1007/s00210-008-0363-y
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat
A role for atorvastatin and insulin combination.pdf430.04 kBAdobe PDFView/Open
Show full item record

SCOPUSTM   
Citations

20
checked on Nov 17, 2022

WEB OF SCIENCETM
Citations 50

19
checked on Nov 15, 2022

Page view(s)

346
checked on Mar 26, 2024

Download(s)

340
checked on Mar 26, 2024

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.