Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/10524
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dc.contributor.authorNijst, Christiaan L. E.-
dc.contributor.authorBruggeman, Joost P.-
dc.contributor.authorKarp, Jeffrey M.-
dc.contributor.authorFerreira, Lino-
dc.contributor.authorZumbuehl, Andreas-
dc.contributor.authorBettinger, Christopher J.-
dc.contributor.authorLanger, Robert-
dc.date.accessioned2009-07-07T10:31:25Z-
dc.date.available2009-07-07T10:31:25Z-
dc.date.issued2007-10-08-
dc.identifier.citationBiomacromolecules. 8:10 (2007) 3067-3073en_US
dc.identifier.issn1525-7797-
dc.identifier.urihttp://hdl.handle.net/10316/10524-
dc.description.abstractElastomeric networks are increasingly being investigated for a variety of biomedical applications including drug delivery and tissue engineering. However, in some cases, their preparation requires the use of harsh processing conditions (e.g., high temperature), which limits their biomedical application. Herein, we demonstrate the ability to form elastomeric networks from poly(glycerol-co-sebacate) acrylate (PGSA) under mild conditions while preserving a wide range of physical properties. These networks presented a Young's modulus between 0.05 and 1.38 MPa, an ultimate strength from 0.05 to 0.50 Mpa, and elongation at break between 42% and 189% strain, by varying the degree of acrylation (DA) of PGSA. The in vitro enzymatic and hydrolytic degradation of the polymer networks was dependent on the DA. The copolymerization of poly(ethylene glycol) diacrylate with PGSA allowed for an additional control of mechanical properties and swelling ratios in an aqueous environment, as well as enzymatic and hydrolytic degradation. Photocured PGSA networks demonstrated in vitro biocompatibility as judged by sufficient human primary cell adherence and subsequent proliferation into a confluent monolayer. These photocurable degradable elastomers could have potential application for the encapsulation of temperature-sensitive factors and cells for tissue engineering.en_US
dc.language.isoengen_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsopenAccesseng
dc.titleSynthesis and Characterization of Photocurable Elastomers from Poly(glycerol-co-sebacate)en_US
dc.typearticleen_US
dc.identifier.doi10.1021/bm070423u-
item.languageiso639-1en-
item.fulltextCom Texto completo-
item.grantfulltextopen-
crisitem.author.deptFaculty of Medicine-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.orcid0000-0001-8985-9302-
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
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