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Title: Subpopulations of High-Density Lipoprotein: Friends or Foes in Cardiovascular Disease Risk in Chronic Kidney Disease?
Authors: Coimbra, Susana
Reis, Flávio 
Valente, Maria João 
Rocha, Susana
Catarino, Cristina
Rocha-Pereira, Petronila 
Sameiro-Faria, Maria
Bronze-da-Rocha, Elsa
Belo, Luís
Santos-Silva, Alice
Keywords: HDL subpopulations; cardiovascular disease risk; chronic kidney disease; inflammation; oxidative stress; HDL functionality
Issue Date: 16-May-2021
Publisher: MDPI AG
Project: UIDP/04539/2020 (CIBB) 
PO-CI-01-0145-FEDER- 007440 
Serial title, monograph or event: Biomedicines
Volume: 9
Issue: 5
Abstract: Dyslipidemia is a major traditional risk factor for cardiovascular disease (CVD) in chronic kidney disease (CKD) patients, although the altered lipid profile does not explain the number and severity of CVD events. High-density lipoprotein (HDL) is a heterogeneous (size, composition, and functionality) population of particles with different atherogenic or atheroprotective properties. HDL-cholesterol concentrations per se may not entirely reflect a beneficial or a risk profile for CVD. Large HDL in CKD patients may have a unique proteome and lipid composition, impairing their cholesterol efflux capacity. This lack of HDL functionality may contribute to the paradoxical coexistence of increased large HDL and enhanced risk for CVD events. Moreover, CKD is associated with inflammation, oxidative stress, diabetes, and/or hypertension that are able to interfere with the anti-inflammatory, antioxidative, and antithrombotic properties of HDL subpopulations. How these changes interfere with HDL functions in CKD is still poorly understood. Further studies are warranted to fully clarify if different HDL subpopulations present different functionalities and/or atheroprotective effects. To achieve this goal, the standardization of techniques would be valuable.
ISSN: 2227-9059
DOI: 10.3390/biomedicines9050554
Rights: openAccess
Appears in Collections:I&D CIBB - Artigos em Revistas Internacionais
I&D ICBR - Artigos em Revistas Internacionais

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