Utilize este identificador para referenciar este registo: http://hdl.handle.net/10316/103756
Título: Connecting different heart diseases through intercellular communication
Autor: Martins-Marques, Tânia 
Palavras-chave: Gap junctions; Extracellular vesicles; Tunneling nanotubes; Cell-based therapies; Myocardial infarction; Cardiac hypertrophy
Data: 15-Set-2021
Editora: The Company of Biologists Ltd.
Projeto: CENTRO-01-0145-FEDER-000012-N2323 
POCI- 01-0145-FEDER-022122 
European Cooperation in Science and Technology (COST) Action EUCARDIOPROTECTION CA16225 
Título da revista, periódico, livro ou evento: Biology Open
Volume: 10
Número: 9
Resumo: Well-orchestrated intercellular communication networks are pivotal to maintaining cardiac homeostasis and to ensuring adaptative responses and repair after injury. Intracardiac communication is sustained by cell-cell crosstalk, directly via gap junctions (GJ) and tunneling nanotubes (TNT), indirectly through the exchange of soluble factors and extracellular vesicles (EV), and by cell-extracellular matrix (ECM) interactions. GJ-mediated communication between cardiomyocytes and with other cardiac cell types enables electrical impulse propagation, required to sustain synchronized heart beating. In addition, TNT-mediated organelle transfer has been associated with cardioprotection, whilst communication via EV plays diverse pathophysiological roles, being implicated in angiogenesis, inflammation and fibrosis. Connecting various cell populations, the ECM plays important functions not only in maintaining the heart structure, but also acting as a signal transducer for intercellular crosstalk. Although with distinct etiologies and clinical manifestations, intercellular communication derailment has been implicated in several cardiac disorders, including myocardial infarction and hypertrophy, highlighting the importance of a comprehensive and integrated view of complex cell communication networks. In this review, I intend to provide a critical perspective about the main mechanisms contributing to regulate cellular crosstalk in the heart, which may be considered in the development of future therapeutic strategies, using cell-based therapies as a paradigmatic example. This Review has an associated Future Leader to Watch interview with the author.
URI: http://hdl.handle.net/10316/103756
ISSN: 2046-6390
DOI: 10.1242/bio.058777
Direitos: openAccess
Aparece nas coleções:FMUC Medicina - Artigos em Revistas Internacionais
I&D CIBB - Artigos em Revistas Internacionais
I&D ICBR - Artigos em Revistas Internacionais

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