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Title: | Plasmatic Oxidative and Metabonomic Profile of Patients with Different Degrees of Biliary Acute Pancreatitis Severity | Authors: | Silva-Vaz, Pedro Jarak, Ivana Rato, Luis Oliveira, Pedro F. Morgado-Nunes, Sara Paulino, Aida Castelo-Branco, Miguel Botelho, Filomena Tralhão, José Guilherme Alves, Marco G. Abrantes, Ana Margarida |
Keywords: | acute biliary pancreatitis; inflammation; prognostic; severity; hepcidin; systemic inflammatory response index; oxidative stress; metabonomics | Issue Date: | 21-Jun-2021 | Project: | UID/NEU/04539/2019 UIDB/04539/2020 UIDP/04539/2020 (CIBB) FCT - IFCT2015 UMIB (UIDB/00215/2020) UIDP/00215/2020 REEQ/481/QUI/2006 RECI/QEQ-QFI/0168/2012 CENTRO-07-CT62-FEDER-002012 Rede Nacional de Ressonância Magnética Nuclear (RNRMN) |
Serial title, monograph or event: | Antioxidants | Volume: | 10 | Issue: | 6 | Abstract: | Acute pancreatitis (AP) is an inflammatory process of the pancreas with variable involvement of the pancreatic and peripancreatic tissues and remote organ systems. The main goal of this study was to evaluate the inflammatory biomarkers, oxidative stress (OS), and plasma metabolome of patients with different degrees of biliary AP severity to improve its prognosis. Twenty-nine patients with biliary AP and 11 healthy controls were enrolled in this study. We analyzed several inflammatory biomarkers, multifactorial scores, reactive oxygen species (ROS), antioxidants defenses, and the plasma metabolome of biliary AP and healthy controls. Hepcidin (1.00), CRP (0.94), and SIRI (0.87) were the most accurate serological biomarkers of AP severity. OS played a pivotal role in the initial phase of AP, with significant changes in ROS and antioxidant defenses relating to AP severity. Phenylalanine (p < 0.05), threonine (p < 0.05), and lipids (p < 0.01) showed significant changes in AP severity. The role of hepcidin and SIRI were confirmed as new prognostic biomarkers of biliary AP. OS appears to have a role in the onset and progression of the AP process. Overall, this study identified several metabolites that may predict the onset and progression of biliary AP severity, constituting the first metabonomic study in the field of biliary AP. | URI: | https://hdl.handle.net/10316/103684 | ISSN: | 2076-3921 | DOI: | 10.3390/antiox10060988 | Rights: | openAccess |
Appears in Collections: | FFUC- Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais I&D ICBR - Artigos em Revistas Internacionais I&D CIBB - Artigos em Revistas Internacionais |
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