Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/10112
DC FieldValueLanguage
dc.contributor.authorAlves, Gilberto-
dc.contributor.authorFigueiredo, Isabel-
dc.contributor.authorFalcão, Amílcar-
dc.contributor.authorCastel-Branco, Margarida-
dc.contributor.authorCaramona, Margarida-
dc.contributor.authorSoares-da-Silva, Patrício-
dc.date.accessioned2009-04-30T14:07:42Z-
dc.date.available2009-04-30T14:07:42Z-
dc.date.issued2008-
dc.identifier.citationChirality. 20:6 (2008) 796-804-
dc.identifier.otherDOI: 10.1002/chir.20546-
dc.identifier.urihttps://hdl.handle.net/10316/10112-
dc.description.abstractThe stereoselective disposition of S-licarbazepine (S-Lic) and R-licarbazepine (R-Lic) was investigated in plasma, brain, liver, and kidney tissues after their individual administration (350 mg/kg) to mice by oral gavage. Plasma, brain, liver, and kidney concentrations of licarbazepine enantiomers and their metabolites were determined over the time by a validated chiral HPLC-UV method. The mean concentration data, attained at each time point, were analyzed using a non-compartmental model. S-Lic and R-Lic were rapidly absorbed from gastrointestinal tract of mouse and immediately distributed to tissues supplied with high blood flow rates. Both licarbazepine enantiomers were metabolized to a small extent, each parent compound being mainly responsible for the systemic and tissue drug exposure. The stereoselectivity in the metabolism and distribution of S- and R-Lic was easily identified. An additional metabolite was detected following R-Lic administration and S-Lic showed a particular predisposition for hepatic and renal accumulation. Stereoselective processes were also identified at the blood-brain barrier, with the brain exposure to S-Lic almost twice that of R-Lic. Another finding, reported here for the first time, was the ability of the mouse to perform the chiral inversion of S- and R-Lic, albeit to a small extent. Chirality, 2008. © 2008 Wiley-Liss, Inc.-
dc.format.mimetypeaplication/PDF-
dc.language.isoeng-
dc.publisherWiley Interscience-
dc.relationSFRH/12694/2003-
dc.rightsopenAccess-
dc.subjectstereoselectivity-
dc.subjectlicarbazepine enantiomers-
dc.subjecteslicarbazepine acetate-
dc.subjectoxcarbazepine-
dc.subjectpharmacokinetics-
dc.subjectchiral separation-
dc.subjectmouse plasma-
dc.subjectmouse tissues-
dc.titleStereoselective disposition of S and R-licarbazepine in mice-
dc.typearticle-
degois.publication.firstPage796-
degois.publication.lastPage804-
degois.publication.issue6-
degois.publication.titleChirality-
dc.date.updated2022-07-30T22:18:35Z-
dc.identifier.doi10.1002/chir.20546-
degois.publication.volume20-
dc.description.version3910-3178-31BA | MARIA MARGARIDA COUTINHO DE SEABRA CASTEL-BRANCO CAETANO-
dc.description.versioninfo:eu-repo/semantics/publishedVersion-
item.openairetypearticle-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.fulltextCom Texto completo-
crisitem.author.researchunitICBR Coimbra Institute for Clinical and Biomedical Research-
crisitem.author.parentresearchunitFaculty of Medicine-
crisitem.author.orcid0000-0002-3854-6549-
crisitem.author.orcid0000-0002-6533-9932-
crisitem.author.orcid0000-0003-1950-9360-
Appears in Collections:FFUC- Artigos em Revistas Internacionais
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