Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/100510
DC FieldValueLanguage
dc.contributor.authorConte, Fernanda Lopes-
dc.contributor.authorPereira, Ana Catarina-
dc.contributor.authorBrites, Gonçalo-
dc.contributor.authorFerreira, Isabel-
dc.contributor.authorSilva, Ana Cristina-
dc.contributor.authorSebastião, Ana Isabel-
dc.contributor.authorMatos, Patrícia-
dc.contributor.authorPereira, Cláudia-
dc.contributor.authorBatista, Maria Teresa-
dc.contributor.authorSforcin, José Maurício-
dc.contributor.authorCruz, Maria Teresa-
dc.date.accessioned2022-06-27T12:47:33Z-
dc.date.available2022-06-27T12:47:33Z-
dc.date.issued2022-
dc.identifier.issn26670313pt
dc.identifier.urihttp://hdl.handle.net/10316/100510-
dc.description.abstractPropolis is a bee product used since ancient times due to its diverse biological applications. We aimed to investigate the antioxidant and anti-inflammatory action of Brazilian propolis in THP-1 cells stimulated with 1‐fluoro‐2,4‐dinitrobenzene (DNFB) or lipopolysaccharide (LPS). Methods: Cell viability was assessed by resazurin assay, antioxidant activity was evaluated by DPPH assay, superoxide dismutase (SOD) 1 and 2 activity was evaluated by colorimetric assay. CD86 expression was determined by flow cytometry. IL-1β and HMOX-1 were analysed by Western blot. Results: Propolis did not affect cell viability and exhibited a potent antioxidant activity. Propolis alone induced SOD 1 activity. LPS stimulated SOD2, concomitantly or not with propolis. In the presence of LPS, propolis induced a higher HMOX-1 expression. Propolis inhibited CD86 expression stimulated by DNFB. LPS induced pro-IL-1β expression and propolis did not affect its action. Conclusion: Propolis exhibited an antioxidant action in a cell-free system and in a cell based-model. Propolis exerted an anti-inflammatory/antiallergic action, probably due to its antioxidant activity.pt
dc.language.isoengpt
dc.relationCoordenação de Aperfeiçoamento de Pessoal de Nível Superior/Programa Institucional de Internacionalização (CAPES/PRINT) under grant number: 88887.467268/2019–00pt
dc.relationFCTpt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt
dc.subjectAnti-inflammatory actionpt
dc.subjectAntiallergic actionpt
dc.subjectAntioxidant activitypt
dc.subjectMonocytept
dc.subjectPropolispt
dc.titleExploring the antioxidant, anti-inflammatory and antiallergic potential of Brazilian propolis in monocytespt
dc.typearticle-
degois.publication.firstPage100231pt
degois.publication.issue2pt
degois.publication.titlePhytomedicine Pluspt
dc.peerreviewedyespt
dc.identifier.doi10.1016/j.phyplu.2022.100231pt
degois.publication.volume2pt
dc.date.embargo2022-01-01*
uc.date.periodoEmbargo0pt
item.grantfulltextopen-
item.fulltextCom Texto completo-
item.languageiso639-1en-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.deptFaculty of Pharmacy-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Pharmacy-
crisitem.author.deptFaculty of Pharmacy-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.orcid0000-0002-2279-9461-
crisitem.author.orcid0000-0002-1687-2968-
crisitem.author.orcid0000-0002-6630-5056-
crisitem.author.orcid0000-0003-4183-6202-
crisitem.author.orcid0000-0001-9846-6754-
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais
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