Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/100510
DC Field | Value | Language |
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dc.contributor.author | Conte, Fernanda Lopes | - |
dc.contributor.author | Pereira, Ana Catarina | - |
dc.contributor.author | Brites, Gonçalo | - |
dc.contributor.author | Ferreira, Isabel | - |
dc.contributor.author | Silva, Ana Cristina | - |
dc.contributor.author | Sebastião, Ana Isabel | - |
dc.contributor.author | Matos, Patrícia | - |
dc.contributor.author | Pereira, Cláudia | - |
dc.contributor.author | Batista, Maria Teresa | - |
dc.contributor.author | Sforcin, José Maurício | - |
dc.contributor.author | Cruz, Maria Teresa | - |
dc.date.accessioned | 2022-06-27T12:47:33Z | - |
dc.date.available | 2022-06-27T12:47:33Z | - |
dc.date.issued | 2022 | - |
dc.identifier.issn | 26670313 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/100510 | - |
dc.description.abstract | Propolis is a bee product used since ancient times due to its diverse biological applications. We aimed to investigate the antioxidant and anti-inflammatory action of Brazilian propolis in THP-1 cells stimulated with 1‐fluoro‐2,4‐dinitrobenzene (DNFB) or lipopolysaccharide (LPS). Methods: Cell viability was assessed by resazurin assay, antioxidant activity was evaluated by DPPH assay, superoxide dismutase (SOD) 1 and 2 activity was evaluated by colorimetric assay. CD86 expression was determined by flow cytometry. IL-1β and HMOX-1 were analysed by Western blot. Results: Propolis did not affect cell viability and exhibited a potent antioxidant activity. Propolis alone induced SOD 1 activity. LPS stimulated SOD2, concomitantly or not with propolis. In the presence of LPS, propolis induced a higher HMOX-1 expression. Propolis inhibited CD86 expression stimulated by DNFB. LPS induced pro-IL-1β expression and propolis did not affect its action. Conclusion: Propolis exhibited an antioxidant action in a cell-free system and in a cell based-model. Propolis exerted an anti-inflammatory/antiallergic action, probably due to its antioxidant activity. | pt |
dc.language.iso | eng | pt |
dc.relation | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior/Programa Institucional de Internacionalização (CAPES/PRINT) under grant number: 88887.467268/2019–00 | pt |
dc.relation | FCT | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | pt |
dc.subject | Anti-inflammatory action | pt |
dc.subject | Antiallergic action | pt |
dc.subject | Antioxidant activity | pt |
dc.subject | Monocyte | pt |
dc.subject | Propolis | pt |
dc.title | Exploring the antioxidant, anti-inflammatory and antiallergic potential of Brazilian propolis in monocytes | pt |
dc.type | article | - |
degois.publication.firstPage | 100231 | pt |
degois.publication.issue | 2 | pt |
degois.publication.title | Phytomedicine Plus | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1016/j.phyplu.2022.100231 | pt |
degois.publication.volume | 2 | pt |
dc.date.embargo | 2022-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
item.languageiso639-1 | en | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0002-3269-0865 | - |
crisitem.author.orcid | 0000-0002-2279-9461 | - |
crisitem.author.orcid | 0000-0002-4041-0376 | - |
crisitem.author.orcid | 0000-0002-1687-2968 | - |
crisitem.author.orcid | 0000-0003-2047-648X | - |
crisitem.author.orcid | 0000-0002-6630-5056 | - |
crisitem.author.orcid | 0000-0003-4183-6202 | - |
crisitem.author.orcid | 0000-0001-9846-6754 | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais FFUC- Artigos em Revistas Internacionais |
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1-s2.0-S2667031322000173-main.pdf | 3.69 MB | Adobe PDF | View/Open |
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