Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/100221
Title: Slow fluctuations in ongoing brain activity decrease in amplitude with ageing yet their impact on task-related evoked responses is dissociable from behavior
Authors: Ribeiro, Maria 
Castelo-Branco, Miguel 
Keywords: EEG; aging; brain variability; human; neuroscience; pupil; reaction time variability
Issue Date: 24-May-2022
Publisher: eLife Sciences Publications
Project: info:eu-repo/grantAgreement/FCT/UID/4950/2020/PT/CIBIT 
info:eu-repo/grantAgreement/FCT/3599-PPCDT/DSAIPA/DS/0041/2020/PT/A clinical documentation system interfacing clinical and data scientist needs to address the COVID challenge 
info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC/PSI-GER/30852/2017/PT/EFFECTIVE BRAIN CONNECTIVITY OF DECISION AND ERROR MONITORING CIRCUITS IN HEALTH AND DISEASE: FROM NEUROCOGNITION TO BRAIN COMPUTER INTERFACES 
info:eu-repo/grantAgreement/FCT/3599-PPCDT/EXPL/PSI-GER/0349/2021/PT/A functional account of the noradrenergic system in healthy ageing and decision-making 
Serial title, monograph or event: eLife
Volume: 11
Abstract: In humans, ageing is characterized by decreased brain signal variability and increased behavioral variability. To understand how reduced brain variability segregates with increased behavioral variability, we investigated the association between reaction time variability, evoked brain responses and ongoing brain signal dynamics, in young (N=36) and older adults (N=39). We studied the electroencephalogram (EEG) and pupil size fluctuations to characterize the cortical and arousal responses elicited by a cued go/no-go task. Evoked responses were strongly modulated by slow (<2 Hz) fluctuations of the ongoing signals, which presented reduced power in the older participants. Although variability of the evoked responses was lower in the older participants, once we adjusted for the effect of the ongoing signal fluctuations, evoked responses were equally variable in both groups. Moreover, the modulation of the evoked responses caused by the ongoing signal fluctuations had no impact on reaction time, thereby explaining why although ongoing brain signal variability is decreased in older individuals, behavioral variability is not. Finally, we showed that adjusting for the effect of the ongoing signal was critical to unmask the link between neural responses and behavior as well as the link between task-related evoked EEG and pupil responses.
URI: http://hdl.handle.net/10316/100221
ISSN: 2050-084X
DOI: 35608164
2050-084X
35608164
2050-084X
2050-084X
35608164
10.7554/eLife.75722
Rights: openAccess
Appears in Collections:I&D CIBIT - Artigos em Revistas Internacionais
FMUC Medicina - Artigos em Revistas Internacionais
I&D ICNAS - Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat
elife-75722-v1.pdf7.12 MBAdobe PDFView/Open
Show full item record

Google ScholarTM

Check

Altmetric

Altmetric


This item is licensed under a Creative Commons License Creative Commons