Rego, A. Cristina

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Credit Name
Rego, A. Cristina
 
Name
Rego, A. Cristina
 
Variants
Rego, Ana Cristina
Rego, A. C.
 
Unidade de I&D
 
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Ciência ID
 
Status
UC Researcher
Biography
Ana Cristina Rego (Ph.D.) is Associate Professor at the Faculty of Medicine, University of Coimbra (FMUC), lecturing classes of Biochemistry, Neuroscience and Neurobiology, and is head of the research group ‘Mitochondria and Neurodegenerative Disorders’ (current designation) at the Center for Neuroscience and Cell Biology (CNC), Univ. Coimbra (UC), since 2003. AC Rego initiated as Teaching Assistant in 1997 at FMUC, was Assistant Professor since 1999, and received the Tenure positition in 2004 and the 'Agregação' degree in 2010. AC Rego obtained the Master degree in Cell Biology in 1994 and the Ph.D. in Cell Biology in 1999 at UC, under the supervision of Prof. Catarina R. Oliveira, and was postdoctoral researcher in the Lab of Prof. David G. Nicholls, at the Univ. Dundee, Scotland, UK, and visiting researcher at the Buck Institute, Novato, CA, USA (David Nicholls Lab), from 1998-2000. In 2004-05 AC Rego was the coordinator of the BEB PhD Programme at CNC. The research group coordinated by AC Rego at CNC-UC investigates molecular mechanisms of familial and age-related neurodegenerative disorders, including Huntington’s and Alzheimer’s diseases, focusing on changes in mitochondrial function, dynamics and biogenesis and metabolic deregulation, glutamatergic postsynaptic dysfunction, and related exosomal content. Funding has been garnered by HighQ Foundation (USA), Lundbeck Foundation, ‘Instituto de Investigação Interdisciplinar’ (IIIUC), ‘Fundação para a Ciência e a Tecnologia’ (FCT) and EHDN-European Huntington Disease Network projects, two 1st edition major‘prizes/awards promoted by Santa Casa da Misericórdia de Lisboa’ (SCML) and ‘Fundação Luso Americana para o Desenvolvimento’ (FLAD) , as well as through industry contracts (e.g. TEVA, Sigma-Tau, Mycology Lab). AC Rego holds a H-factor of 44 (i10=98, at Google Scholar) and ~6400 citations, published 117 peer-reviewed articles (92 original publications), 23 book chapters (11 in portuguese) and more than 110 abstracts in research meetings. AC Rego also supervised/co-supervised the work of several post-doctoral fellows and a 'Ciência-FCT' researcher, 18 Ph.D. students and 37 Master students (concluded degrees). AC Rego acts as a reviewer for scientific journals and funding bodies, including Parkinson's UK, Alzheimer’s Research UK, Austrian Science Fund (FWF), Agence Nationale de la Recherche (ANR), Auckland Medical Research Foundation (AMRF), Telethon Fondazione, Israel Science Foundation, Wellcome Trust and Alzheimer’s Association. ACR is member of the ERA-Chair recruitment and monitoring team ERAatUC, at University of Coimbra, member of the board of CNC-UC, Vice-President of the Portuguese Brain Council and President of the Portuguese Society for Neuroscience (SPN).
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Publications

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Date Issued:  [2020 TO 2023]

Results 1-18 of 18 (Search time: 0.021 seconds).

Issue DateTitleAuthor(s)TypeAccess
11-Jan-2023Apoe4 and Alzheimer's Disease Pathogenesis-Mitochondrial Deregulation and Targeted Therapeutic StrategiesPires, Mariana ; Rego, A. Cristina articleopenAccess
22021Boldine Attenuates Synaptic Failure and Mitochondrial Deregulation in Cellular Models of Alzheimer's DiseaseToledo, Juan P.; Fernández-Pérez, Eduardo J.; Ferreira, Ildete L. ; Marinho, Daniela ; Riffo-Lepe, Nicolas O.; Pineda-Cuevas, Benjamin N.; Pinochet-Pino, Luis F.; Burgos, Carlos F.; Rego, A. Cristina ; Aguayo, Luis G.articleopenAccess
37-Feb-2020Calcium Signaling in Aging and Neurodegenerative Diseases 2019Cortes, Luísa ; Malva, João ; Rego, Ana Cristina ; Pereira, Cláudia F. articleopenAccess
42023Extracellular vesicles improve GABAergic transmission in Huntington's disease iPSC-derived neuronsBeatriz, Margarida ; Rodrigues, Ricardo J. ; Vilaça, Rita ; Egas, Conceição ; Pinheiro, Paulo S. ; Daley, George Q.; Schlaeger, Thorsten M.; Raimundo, Nuno ; Rego, A. Cristina ; Lopes, Carla articleopenAccess
524-Feb-2021Linking mitochondrial Src and hippocampal dendritic changes in Alzheimer's diseaseNeves, Laura Alexandrina SequeiramasterThesisopenAccess
65-Nov-2021Macroautophagy and Mitophagy in Neurodegenerative Disorders: Focus on Therapeutic InterventionsMagalhães, João Duarte; Fão, Lígia ; Vilaça, Rita ; Cardoso, Sandra Morais ; Rego, A. Cristina articleopenAccess
75-Nov-2020Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation, and Alzheimer's disease features in cortical neuronsSilva, Diana F. ; Candeias, Emanuel ; Esteves, Ana Raquel Fernandes ; Magalhães, João Duarte ; Ferreira, I. Luísa ; Nunes-Costa, Daniela ; Rego, Ana Cristina ; Empadinhas, Nuno ; Cardoso, Sandra M. articleopenAccess
818-Jan-2023Mitochondrial and Redox Changes in Periodontitis and Type 2 Diabetes Human Blood Mononuclear CellsFerreira, Ildete L. ; Costa, Solange ; Moraes, Bruno; Costa, Ana ; Fokt, Olga ; Marinho, Daniela ; Alves, Vera ; Baptista, Isabel P. ; Rego, A. Cristina articleopenAccess
92020Mitochondrial and Redox Modifications in Huntington Disease Induced Pluripotent Stem Cells Rescued by CRISPR/Cas9 CAGs TargetingLopes, Carla ; Tang, Yang; Anjo, Sandra I. ; Manadas, Bruno ; Onofre, Isabel ; Almeida, Luís P. de ; Daley, George Q; Schlaeger, Thorsten M; Rego, Ana Cristina Carvalho articleopenAccess
104-Jun-2020Mitochondrial and redox-based therapeutic strategies in Huntington's diseaseFão, Lígia ; Rego, Ana Cristina articleopenAccess
1116-Nov-2020Mitochondrial dynamics and mitophagy in cellular models of Parkinson's DiseaseSantos, Bruno Miguel Sequeira dosmasterThesisopenAccess
123-Oct-2023Mitochondrial Dysfunction and Decreased Cytochrome c in Cell and Animal Models of Machado-Joseph DiseaseAlmeida, Filipa ; Ferreira, Ildete L. ; Naia, Luana ; Marinho, Daniela ; Vilaça-Ferreira, Ana Catarina; Costa, Marta D.; Duarte-Silva, Sara; Maciel, Patrícia ; Rego, A. Cristina articleopenAccess
132021MPV17 Mutations Are Associated With a Quiescent Energetic Metabolic ProfileJacinto, Sandra; Guerreiro, Patrícia; Oliveira, Rita Machado de; Oliveira, Teresa Cunha ; Santos, Maria João ; Grazina, Manuela ; Rego, A. Cristina ; Outeiro, Tiago F. articleopenAccess
1424-Mar-2021Neuronal cell-based high-throughput screen for enhancers of mitochondrial function reveals luteolin as a modulator of mitochondria-endoplasmic reticulum couplingNaia, Luana Carvalho ; Pinho, Catarina M.; Dentoni, Giacomo; Liu, Jianping; Leal, Nuno Santos; Ferreira, Duarte M. S.; Schreiner, Bernadette; Filadi, Riccardo; Fão, Lígia ; Connolly, Niamh M. C.; Forsell, Pontus; Nordvall, Gunnar; Shimozawa, Makoto; Greotti, Elisa; Basso, Emy; Theurey, Pierre; Gioran, Anna; Joselin, Alvin; Arsenian-Henriksson, Marie; Nilsson, Per; Rego, A. Cristina ; Ruas, Jorge L.; Park, David; Bano, Daniele; Pizzo, Paola; Prehn, Jochen H. M.; Ankarcrona, MariaarticleopenAccess
159-Nov-2021Neuroprotection of retinal ganglion cells by the sigma-1 receptor agonist pridopidine in models of experimental glaucomaGeva, Michal; Gershoni-Emek, Noga; Naia, Luana ; Ly, Philip; Mota, Sandra ; Rego, Ana Cristina ; Hayden, Michael R. ; Levin, Leonard A.articleopenAccess
16Aug-2023Reduction of class I histone deacetylases ameliorates ER-mitochondria cross-talk in Alzheimer's diseaseMarinho, Daniela ; Ferreira, Ildete L. ; Lorenzoni, Ricardo ; Cardoso, Sandra M. ; Santana, Isabel ; Rego, A. Cristina articleopenAccess
172022Simultaneous Alteration of the Circadian Variation of Memory, Hippocampal Synaptic Plasticity, and Metabolism in a Triple Transgenic Mouse Model of Alzheimer's DiseaseCarvalho da Silva, António M ; Lemos, Cristina ; Silva, Henrique Bernardo ; Ferreira, Ildete L. ; Tomé, Ângelo R.; Rego, A. Cristina ; Cunha, Rodrigo A. articleopenAccess
1816-Sep-2023Uncovering the Early Events Associated with Oligomeric Aβ-Induced Src ActivationMota, Sandra ; Fão, Lígia ; Coelho, Patrícia Silva ; Rego, A. Cristina articleopenAccess