Rego, A. Cristina
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Rego, A. Cristina
Name
Rego, A. Cristina
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Rego, Ana Cristina
Rego, A. C.
Rego, A. C.
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UC Researcher
Biography
Ana Cristina Rego (Ph.D.) is Associate Professor at the Faculty of Medicine, University of Coimbra (FMUC), lecturing classes of Biochemistry, Neuroscience and Neurobiology, and is head of the research group ‘Mitochondria and Neurodegenerative Disorders’ (current designation) at the Center for Neuroscience and Cell Biology (CNC), Univ. Coimbra (UC), since 2003. AC Rego initiated as Teaching Assistant in 1997 at FMUC, was Assistant Professor since 1999, and received the Tenure positition in 2004 and the 'Agregação' degree in 2010. AC Rego obtained the Master degree in Cell Biology in 1994 and the Ph.D. in Cell Biology in 1999 at UC, under the supervision of Prof. Catarina R. Oliveira, and was postdoctoral researcher in the Lab of Prof. David G. Nicholls, at the Univ. Dundee, Scotland, UK, and visiting researcher at the Buck Institute, Novato, CA, USA (David Nicholls Lab), from 1998-2000. In 2004-05 AC Rego was the coordinator of the BEB PhD Programme at CNC. The research group coordinated by AC Rego at CNC-UC investigates molecular mechanisms of familial and age-related neurodegenerative disorders, including Huntington’s and Alzheimer’s diseases, focusing on changes in mitochondrial function, dynamics and biogenesis and metabolic deregulation, glutamatergic postsynaptic dysfunction, and related exosomal content. Funding has been garnered by HighQ Foundation (USA), Lundbeck Foundation, ‘Instituto de Investigação Interdisciplinar’ (IIIUC), ‘Fundação para a Ciência e a Tecnologia’ (FCT) and EHDN-European Huntington Disease Network projects, two 1st edition major‘prizes/awards promoted by Santa Casa da Misericórdia de Lisboa’ (SCML) and ‘Fundação Luso Americana para o Desenvolvimento’ (FLAD) , as well as through industry contracts (e.g. TEVA, Sigma-Tau, Mycology Lab). AC Rego holds a H-factor of 44 (i10=98, at Google Scholar) and ~6400 citations, published 117 peer-reviewed articles (92 original publications), 23 book chapters (11 in portuguese) and more than 110 abstracts in research meetings. AC Rego also supervised/co-supervised the work of several post-doctoral fellows and a 'Ciência-FCT' researcher, 18 Ph.D. students and 37 Master students (concluded degrees). AC Rego acts as a reviewer for scientific journals and funding bodies, including Parkinson's UK, Alzheimer’s Research UK, Austrian Science Fund (FWF), Agence Nationale de la Recherche (ANR), Auckland Medical Research Foundation (AMRF), Telethon Fondazione, Israel Science Foundation, Wellcome Trust and Alzheimer’s Association. ACR is member of the ERA-Chair recruitment and monitoring team ERAatUC, at University of Coimbra, member of the board of CNC-UC, Vice-President of the Portuguese Brain Council and President of the Portuguese Society for Neuroscience (SPN).
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Results 1-40 of 40 (Search time: 0.067 seconds).
| Issue Date | Title | Author(s) | Type | Access | |
|---|---|---|---|---|---|
| 1 | Feb-2015 | Activation of IGF-1 and Insulin Signaling Pathways Ameliorate Mitochondrial Function and Energy Metabolism in Huntington’s Disease Human Lymphoblasts | Naia, Luana ; Ferreira, I. Luísa ; Cunha-Oliveira, Teresa ; Duarte, Ana I. ; Ribeiro, Márcio ; Rosenstock, Tatiana R. ; Laço, Mário N. ; Ribeiro, Maria J. ; Oliveira, Catarina R. ; Saudou, Frédéric ; Humbert, Sandrine ; Rego, A. Cristina | article | openAccess |
| 2 | 2007 | Adaptation to oxidative stress in the chronic effects of cocaine and amphetamine | Cunha-Oliveira, T. ; Rego, A. C. ; Macedo, T. ; Oliveira, C. R. | article | openAccess |
| 3 | 2000 | Adenosine A2AReceptors Regulate the Extracellular Accumulation of Excitatory Amino Acids upon Metabolic Dysfunction in Chick Cultured Retinal Cells | Rego, Ana Cristina ; Agostinho, Paula ; Melo, Joana ; Cunha, Rodrigo A. ; Oliveira, Catarina R. | article | openAccess |
| 4 | 2001 | Antioxidant effect of flavonoids after ascorbate/Fe2+-induced oxidative stress in cultured retinal cells | Areias, Filipe Miguel ; Rego, A. Cristina ; Oliveira, Catarina R. ; Seabra, Rosa Maria | article | openAccess |
| 5 | Feb-2015 | Aβ and NMDAR activation cause mitochondrial dysfunction involving ER calcium release | Ferreira, Ildete Luísa ; Ferreiro, Elisabete ; Schmidt, Jeannette ; Cardoso, João M. ; Pereira, Cláudia M. F. ; Carvalho, Ana Luísa ; Oliveira, Catarina R. ; Rego, A. Cristina | article | openAccess |
| 6 | 2009 | BDNF regulates BIM expression levels in 3-nitropropionic acid-treated cortical neurons | Almeida, S. ; Laço, M. ; Cunha-Oliveira, T. ; Oliveira, C. R. ; Rego, A. C. | article | openAccess |
| 7 | Sep-2011 | Bioenergetic dysfunction in Huntington's disease human cybrids | Ferreira, I. Luísa ; Cunha-Oliveira, Teresa ; Nascimento, Maria V. ; Ribeiro, Márcio ; Proença, M. Teresa ; Januário, Cristina ; Oliveira, Catarina R. ; Rego, A. Cristina | article | openAccess |
| 8 | 2006 | Caspase-dependent and -independent cell death induced by 3-nitropropionic acid in rat cortical neurons | Almeida, Sandra ; Brett, Ana C. ; Góis, Inês N. ; Oliveira, Catarina R. ; Rego, A. Cristina | article | openAccess |
| 9 | 2008 | Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs | Cunha-Oliveira, Teresa ; Rego, Ana Cristina ; Oliveira, Catarina R. | article | openAccess |
| 10 | 2003 | Cytosolic and mitochondrial ROS in staurosporine-induced retinal cell apoptosis | Gil, Joana ; Almeida, Sandra ; Oliveira, Catarina R. ; Rego, A. Cristina | article | openAccess |
| 11 | 2005 | Differential cytotoxic responses of PC12 cells chronically exposed to psychostimulants or to hydrogen peroxide | Cunha-Oliveira, T. ; Rego, A. C. ; Morgadinho, M. T. ; Sarmento, A. ; Macedo, T. ; Oliveira, C. R. | conferenceObject | openAccess |
| 12 | 2006 | Differential cytotoxic responses of PC12 cells chronically exposed to psychostimulants or to hydrogen peroxide | Cunha-Oliveira, Teresa ; Rego, A. Cristina ; Morgadinho, Maria Teresa ; Macedo, Tice ; Oliveira, Catarina Resende | article | openAccess |
| 13 | 1999 | Distinct Glycolysis Inhibitors Determine Retinal Cell Sensitivity to Glutamate-Mediated Injury | Rego, Ana Cristina ; Areias, Filipe ; Santos, Maria Sancha ; Oliveira, Catarina | article | openAccess |
| 14 | 8-Mar-2012 | Drugs of abuse induce apoptotic features in PC12 cells. | Oliveira, M. Teresa ; Rego, A. Cristina ; Macedo, Tice R. ; Oliveira, Catarina R. | article | openAccess |
| 15 | 2009 | Dysregulation of CREB Activation and Histone Acetylation in 3-Nitropropionic Acid-Treated Cortical Neurons: Prevention by BDNF and NGF | Almeida, Sandra ; Cunha-Oliveira, Teresa ; Laço, Mário ; Oliveira, Catarina R. ; Rego, A. Cristina | article | openAccess |
| 16 | 9-Mar-2012 | Efeito crónico da heroína e do peróxido de hidrogénio em células PC12 | Cunha-Oliveira, Teresa ; Rego, A. Cristina ; Morgadinho, M. Teresa ; Macedo, Tice R. ; Oliveira, Catarina R. | article | openAccess |
| 17 | 2002 | Effect of amyloid beta-peptide on permeability transition pore: A comparative study | Moreira, Paula I. ; Santos, Maria S. ; Moreno, António ; Rego, A. Cristina ; Oliveira, Catarina | article | openAccess |
| 18 | 1998 | Effect of Glucose Deprivation and Acute Glutamate Exposure in Cultured Retinal Cells | Rego, Ana Cristina ; Areias, Filipe Miguel ; Santos, Maria Sancha ; Oliveira, Catarina R. | article | openAccess |
| 19 | 8-Mar-2012 | Expression of NR1/NR2B N-Methyl-d-Aspartate Receptors Enhances Heroin Toxicity in HEK293 Cells | Domingues, António ; Cunha-Oliveira, Teresa ; Laço, Mário L. N. ; Macedo, Tice ; Oliveira, Catarina R. ; Rego, A. Cristina | article | openAccess |
| 20 | 2004 | FK506 prevents mitochondrial-dependent apoptotic cell death induced by 3-nitropropionic acid in rat primary cortical cultures | Almeida, Sandra ; Domingues, António ; Rodrigues, Luís ; Oliveira, Catarina R. ; Rego, A. Cristina | article | openAccess |
| 21 | 2001 | Glutamate regulates the viability of retinal cells in culture | Rego, A. Cristina ; Santos, Maria Sancha ; Areias, Filipe ; Proença, Teresa ; Oliveira, Catarina R. | article | openAccess |
| 22 | 1999 | Glutamate-mediated inhibition of oxidative phosphorylation in cultured retinal cells | Rego, Ana Cristina ; Sancha Santos, Maria ; Oliveira, Catarina Resende | article | openAccess |
| 23 | 15-Nov-2012 | Glutathione redox cycle dysregulation in Huntington’s disease knock-in striatal cells | Ribeiro, Márcio ; Rosenstock, Tatiana ; Cunha-Oliveira, Teresa ; Ferreira, Ildete ; Oliveira, Catarina R. ; Rego, Ana Cristina | article | openAccess |
| 24 | 2005 | Heroin-induced degeneration of cortical neurons involves mitochondria-dependent apoptosis | Cunha-Oliveira, T. ; Rego, A. C. ; Macedo, T. ; Oliveira, C. R. | article | openAccess |
| 25 | 1999 | Influence of the antioxidants vitamin E and idebenone on retinal cell injury mediated by chemical ischemia, hypoglycemia, or oxidative stress | Rego, Ana Cristina ; Santos, Maria Sancha ; Oliveira, Catarina R. | article | openAccess |
| 26 | 1998 | Influence of vitamin E succinate on retinal cell survival | Rego, Ana Cristina ; Santos, Maria Sancha ; Proença, Maria Teresa ; Oliveira, Catarina R. | article | openAccess |
| 27 | Sep-2014 | Insulin and IGF-1 improve mitochondrial function in a PI-3K/Akt-dependent manner and reduce mitochondrial generation of reactive oxygen species in Huntington’s disease knock-in striatal cells | Ribeiro, Márcio ; Rosenstock, Tatiana R. ; Oliveira, Ana M. ; Oliveira, Catarina R. ; Rego, A. Cristina | article | openAccess |
| 28 | Oct-2006 | Insulin restores metabolic function in cultured cortical neurons subjected to oxidative stress | Duarte, Ana I. ; Proença, Teresa ; Oliveira, Catarina R. ; Santos, Maria S. ; Rego, A. Cristina | article | openAccess |
| 29 | 2013 | Medical Toxicology of Drugs of Abuse | Cunha-Oliveira, Teresa ; Rego, Ana Cristina ; Carvalho, Félix ; Oliveira, Catarina R. | bookPart | openAccess |
| 30 | 2003 | Mitochondrial apoptotic cell death and moderate superoxide generation upon selective activation of non-desensitizing AMPA receptors in hippocampal cultures | Rego, A. Cristina ; Monteiro, Nuno M. ; Silva, Ana P. ; Gil, Joana ; Malva, João O. ; Oliveira, Catarina R. | article | openAccess |
| 31 | 2006 | Mitochondrial dysfunction and caspase activation in rat cortical neurons treated with cocaine or amphetamine | Cunha-Oliveira, T. ; Rego, A. C. ; Cardoso, S. M. ; Borges, F. ; Swerdlow, R. ; Macedo, T. ; Oliveira, C. R. | article | openAccess |
| 32 | 2003 | Mitochondrial Dysfunction and Reactive Oxygen Species in Excitotoxicity and Apoptosis: Implications for the Pathogenesis of Neurodegenerative Diseases | Rego, A. Cristina ; Oliveira, Catarina R. | article | openAccess |
| 33 | 2012 | Mitochondrial- and endoplasmic reticulum-associated oxidative stress in Alzheimer's disease: from pathogenesis to biomarkers | Ferreiro, E. ; Baldeiras, I. ; Ferreira, I. L. ; Costa, R. O. ; Rego, A. C. ; Pereira, C. F. ; Oliveira, C. R. | article | openAccess |
| 34 | 2011 | Molecular interaction between cocaine and opioids. Implications on Speedball's toxicity | Cunha-Oliveira, T. ; Silva, L. ; Silva, A. M. ; Santos, M. S. ; Garrido, J. ; Borges, F. ; Rego, A. C. ; Oliveira, C. R. | conferenceObject | openAccess |
| 35 | 2012 | Neurotoxicity of cocaine | Cunha-Oliveira, Teresa ; Rego, A. Cristina ; Oliveira, Catarina R. | bookPart | openAccess |
| 36 | 8-Mar-2012 | Neurotoxicity of heroin-cocaine combinations in rat cortical neurons | Cunha-Oliveira, Teresa ; Rego, A. Cristina ; Garrido, Jorge ; Borges, Fernanda ; Macedo, Tice ; Oliveira, Catarina R. | article | openAccess |
| 37 | 28-Aug-2014 | Oxidative Stress and Drugs of Abuse: An Update | Cunha-Oliveira, Teresa ; Rego, A. Cristina ; Oliveira, Catarina R. | article | openAccess |
| 38 | 2007 | Street heroin induces mitochondrial dysfunction and apoptosis in rat cortical neurons | Cunha-Oliveira, Teresa ; Rego, A. Cristina ; Garrido, Jorge ; Borges, Fernanda ; Macedo, Tice ; Oliveira, Catarina Resende | article | openAccess |
| 39 | Oct-2006 | Synthesis and Cytotoxic Profile of 3,4-Methylenedioxymethamphetamine (“Ecstasy”) and Its Metabolites on Undifferentiated PC12 Cells: A Putative Structure−Toxicity Relationship | Milhazes, Nuno ; Cunha-Oliveira, Teresa ; Martins, Pedro ; Garrido, Jorge ; Oliveira, Catarina ; Rego, A. Cristina ; Borges, Fernanda | article | openAccess |
| 40 | 8-Mar-2012 | Toxic Effects of Opioid and Stimulant Drugs on Undifferentiated PC12 Cells | Oliveira, M. Teresa ; Rego, A. Cristina ; Morgadinho, M. Teresa ; Macedo, Tice R. ; Oliveira, Catarina R. | article | openAccess |