Carvalho, Luís A. E. Batista de
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Credit Name
Carvalho, Luís A. E. Batista de
Name
Carvalho, Luís Batista de
Variants
Carvalho, Luís A. E.
Carvalho, Luís A. E. Batista de
Carvalho, Luís A. E. Batista de
Unidade de I&D
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Researcher ID
Status
UC Researcher
Biography
Luís Alberto E. Batista de Carvalho (January 1961, Coimbra, Portugal) received his BSc (Hons) from the Department of Chemistry, Faculty of Science and Technology, University of Coimbra (1984) and his PhD in Chemistry, specialty Physical-Chemistry, from Faculty of Sciences, University of Lisbon (1993). He is currently associate professor at the Department of Chemistry, University of Coimbra and head of the “Molecular Physical-Chemistry” R&D Unit. Throughout his career he has developed several scientific research projects, in collaboration with national and international groups, in the areas of Medicinal Chemistry, Pharmaceutical Technology and Chemistry/Forensic Anthropology with special emphasis on the application of spectroscopic techniques: i) to the structural analysis of compounds of biological interest; ii) the development of new anti-cancer agents containing Pt and Pd (in particular, the determination of new therapeutic targets in order to optimize efficacy and minimize side effects and acquired resistance); iii) the study of drug/cell interactions in model systems (cancer cell lines) with a view to understanding the molecular mechanisms underlying cytotoxic activity; and iv) the analysis of changes induced by burning processes in human skeletons. He has preferably used vibrational spectroscopy, optical and with neutrons, including microRaman spectroscopy and FTIR with synchrotron radiation. Recently, and in conjunction with the aforementioned themes that he continues to develop, he started a research project that aims to apply vibrational spectroscopy techniques to the early diagnosis of cancer and rigorous determination of surgical margins (in the removal of malignant tumours). This subject involves not only methodological development but also the construction of a new Raman spectroscopy apparatus that increases the speed of diagnosis with a view to translate this technology to the clinics in the near future.
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Publications
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Results 1-52 of 52 (Search time: 0.002 seconds).
| Issue Date | Title | Author(s) | Type | Access | |
|---|---|---|---|---|---|
| 1 | Sep-2013 | A conformational study of hydroxylated isoflavones by vibrational spectroscopy coupled with DFT calculations | Machado, N. F. L. ; Carvalho, L. A. E. Batista de ; Otero, J. C. ; Marques, M. P. M. | article | openAccess |
| 2 | 1-Jan-2017 | An EXAFS Approach to the Study of Polyoxometalate–Protein Interactions: The Case of Decavanadate–Actin | Marques, M. Paula M. ; Gianolio, Diego ; Ramos, Susana ; Carvalho, Luís A. E. Batista de ; Aureliano, Manuel | article | embargoedAccess |
| 3 | 2014 | An inelastic neutron scattering study of dietary phenolic acids | Marques, M. P. M. ; Carvalho, Luís A. E. Batista de ; Valero, Rosendo ; Machado, Nelson F. L. ; Parker, Stewart F. | article | openAccess |
| 4 | 2017 | Ancient burned Human Remains Probed by Neutron and Optical Vibrational Spectroscopy | Festa, G. ; Rickards, O. ; Martinez-Labarga, C. ; Martini, F. ; Marques, M. P. M. ; Carvalho, L. A. E. Batista de ; Gonçalves, D. ; Parker, S. F. ; Andreani, C. | conferenceObject | openAccess |
| 5 | 1-Jan-2017 | Anomalous surface-enhanced Raman scattering of aromatic aldehydes and carboxylic acids | Machado, N. F. L. ; Marques, M. P. M. ; Carvalho, L. A. E. Batista de ; Castro, J. L. ; Otero, J. C. | article | embargoedAccess |
| 6 | 2013 | Applying vibrational spectroscopy to the study of nucleobases – adenine as a case-study | Lopes, Rui P. ; Valero, Rosendo ; Tomkinson, John ; Marques, M. P. M. ; Carvalho, Luís A. E. Batista de | article | openAccess |
| 7 | 2011 | Biologic Activity of a Dinuclear Pd(II)-Spermine Complex Toward Human Breast Cancer | Fiuza, Sónia M. ; Holy, Jon ; Carvalho, Luís A. E. Batista de ; Marques, Maria P. M. | article | openAccess |
| 8 | 2018 | Biomaterials from human bone – probing organic fraction removal by chemical and enzymatic methods | Mamede, A. P. ; Vassalo, A. R. ; Cunha, E. ; Gonçalves, D. ; Parker, S. F. ; Carvalho, L. A. E. Batista de ; Marques, M. P. M. | article | openAccess |
| 9 | 2017 | Burned bones tell their own stories: A review of methodological approaches to assess heat-induced diagenesis | Mamede, Adriana P. ; Gonçalves, David ; Marques, Maria Paula Matos ; Carvalho, Luís A. E. Batista de | article | openAccess |
| 10 | 27-Sep-2017 | Burned Bones: A Comparison of Methodological Approaches to Assess Heat-Induced Alterations | Mamede, Adriana Maria Pires | masterThesis | embargoedAccess |
| 11 | 11-May-2018 | Calixarene functionalization of TiO2 nanoarrays: an effective strategy for enhancing the sensor versatility | Oueslati, Issam ; Ghrairi, Akrem ; Akrem, Edivagner ; Carvalho, Luís ; Gil, João ; Paixão, José António | article | openAccess |
| 12 | 1-Jan-2016 | Characterization of decavanadate and decaniobate solutions by Raman spectroscopy | Aureliano, Manuel ; Ohlin, C. André ; Vieira, Michele O. ; Marques, M. Paula M. ; Casey, William H. ; Carvalho, Luís A. E. Batista de | article | openAccess |
| 13 | 11-Jan-2016 | Chemotherapeutic response to cisplatin-like drugs in human breast cancer cells probed by vibrational microspectroscopy | Carvalho, A. L. M. Batista de ; Pilling, M. ; Gardner, P. ; Doherty, J. ; Cinque, G. ; Wehbe, K. ; Kelley, C. ; Carvalho, L. A. E. Batista de ; Marques, M. P. M. | article | openAccess |
| 14 | 1-Jan-2015 | Comment on “Assessment of new DFT methods for predicting vibrational spectra and structure of cisplatin: Which density functional should we choose for studying platinum(II) complexes?” [Spectrochim. Acta A125 (2014) 431–439] | Marques, Maria Paula M. ; Carvalho, Luís A. E. Batista de ; Parker, Stewart F. | article | openAccess |
| 15 | 2010 | Conformational and vibrational study of cis-diamminedichloropalladium(ii) | Fiuza, Sónia M. ; Amado, Ana M. ; Santos, Hélio F. Dos ; Marques, Maria P. M. ; Carvalho, Luis A. E. Batista de | article | openAccess |
| 16 | 2012 | Conformational behaviour of antioxidant chromones. A vibrational spectroscopy study | Machado, N. F. L. ; Valero, R. ; Domingos, H. S. ; Tomkinson, J. ; Carvalho, L. A. E. Batista de ; Otero, J. C. ; Marques, M. P. M. | article | openAccess |
| 17 | 1-Jan-2015 | Conformational insights and vibrational study of a promising anticancer agent: the role of the ligand in Pd(ii)–amine complexes | Fiuza, Sónia M. ; Amado, Ana M. ; Parker, Stewart F. ; Marques, Maria Paula M. ; Carvalho, Luís A. E. Batista de | article | openAccess |
| 18 | 1-Jan-2016 | Conformational study and reassessment of the vibrational assignments for Norspermidine | Silva, T. M. ; Fiuza, S. M. ; Marques, M. P. M. ; Carvalho, L. A. E. Batista de ; Amado, A. M. | article | openAccess |
| 19 | 1-Jan-2013 | A conformational study of hydroxyflavones by vibrational spectroscopy coupled to DFT calculations | Machado, N. F. L. ; Carvalho, L. A. E. Batista de ; Otero, J. C. ; Marques, M. P. M. | article | openAccess |
| 20 | Jun-2018 | Crystal clear: Vibrational spectroscopy reveals intrabone, intraskeleton, and interskeleton variation in human bones | Gonçalves, D. ; Vassalo, A. R. ; Mamede, A. ; Makhoul, C. ; Piga, G. ; Cunha, E. ; Marques, M. P. M. ; Carvalho, L. A. E. Batista de | article | restrictedAccess |
| 21 | 2012 | Decavanadate, decaniobate, tungstate and molybdate interactions with sarcoplasmic reticulum Ca2+-ATPase: quercetin prevents cysteine oxidation by vanadate but does not reverse ATPase inhibition | Fraqueza, Gil ; Carvalho, Luís A. E. Batista de ; Marques, M. Paula M. ; Maia, Luisa ; Ohlin, C. André ; Casey, William H. ; Aureliano, Manuel | article | openAccess |
| 22 | 2018 | Eating the bone! An enzymatic protocol aiming at bone’s organic matrix removal | Mamede, A. P. ; Vassalo, A. R. ; Gonçalves, David ; Parker, S. F. ; Carvalho, L. A. E. Batista de ; Marques, M. P. M. | conferenceObject | openAccess |
| 23 | Jul-2010 | Estudo teórico e vibracional dos ligandos isopropilamina e pirozole | Padrão, Sara Margarida Miguel | masterThesis | openAccess |
| 24 | 1-Jan-2016 | Faraday Discussions – "Advanced Vibrational Spectroscopy for Biomedical Applications” | Carvalho, A. L. M. Batista de ; Pilling, M. ; Gardner, P. ; Doherty, J. ; Cinque, G. ; Wehbe, K. ; Kelley, C. ; Carvalho, L. A. E. Batista de ; Marques, M. P. M. | bookPart | openAccess |
| 25 | 2012 | Functional and Structural Interactions of Nb, V, Mo and W Oxometalates with the Sarcoplasmic Reticulum Ca2+-ATPase Reveal New Insights Into Inhibition Processes: a Combination of NMR, Raman, AA and EPR Spectroscopies with Kinetic Studies | Fraqueza, G. ; Carvalho, L. A. E. Batista de ; Marques, M. P. M. ; Ohlin, C. A. ; Casey, W. H. ; Aureliano, M. | article | openAccess |
| 26 | 15-Feb-2017 | Geochemical and mineralogical fingerprints to distinguish the exploited ferruginous mineralisations of Grotta della Monaca (Calabria, Italy) | Dimuccio, Luca António ; Rodrigues, Nelson; Larocca, Felice; Pratas, João António Mendes Serra ; Amado, Ana Margarida ; Carvalho, Luís A E Batista de | article | embargoedAccess |
| 27 | 2012 | Guanine: A Combined Study Using Vibrational Spectroscopy and Theoretical Methods | Lopes, R. Pedro ; Marques, M. Paula M. ; Valero, Rosendo ; Tomkinson, John ; Carvalho, Luís A. E. Batista de | article | openAccess |
| 28 | 2018 | Heat-induced Bone Diagenesis Probed by Vibrational Spectroscopy | Marques, M. P. M. ; Mamede, A. P. ; Vassalo, A. R. ; Makhoul, C. ; Cunha, E. ; Gonçalves, D. ; Parker, S. F. ; Carvalho, L. A. E. Batista de | article | openAccess |
| 29 | 25-Sep-2019 | How old are you? An attempt of estimating age at death through FTIR-ATR analysis of human bones and teeth | Guedes, Daniela dos Santos | masterThesis | openAccess |
| 30 | 2011 | Inelastic Neutron Scattering Study of PtII Complexes Displaying Anticancer Properties | Carvalho, Luís A. E. Batista de ; Marques, M. Paula M. ; Martin, Christine ; Parker, Stewart F. ; Tomkinson, John | article | openAccess |
| 31 | 23-Sep-2015 | A influência do conteúdo em colagénio na deformação térmico-induzida de ossos queimados - contributos da espectroscopia vibracional | Fonseca, Ana Rita Vassalo | masterThesis | closedAccess |
| 32 | 25-Jan-2017 | Intracellular water - an overlooked drug target? Cisplatin impact in cancer cells probed by neutrons | Marques, M. P. M. ; Carvalho, A. L. M. Batista de ; Sakai, V Garcia ; Hatter, L ; Carvalho, L. A. E. Batista de | article | embargoedAccess |
| 33 | 2018 | Le potentiel des groupes hydroxyles de la bioapatite pour discriminer des os brulés humains par spectroscopie vibrationelle | Gonçalves, David ; Mamede, Adriana P. ; Vassalo, Ana Rita ; Piga, Giampaolo ; Cunha, Eugénia ; Parker, Stewart F. ; Marques, Maria Paula Matos ; Carvalho, Luís A. E. Batista de | conferenceObject | openAccess |
| 34 | 1-Jan-2013 | Main Symposia And Workshops | Fiuza, S. M. ; Amado, A.M. ; Marques, M. P. M. ; Carvalho, L. A. E. Batista de | article | openAccess |
| 35 | 21-Feb-2015 | A molecular view of cisplatin's mode of action: interplay with DNA bases and acquired resistance | Marques, M. P. M. ; Gianolio, Diego ; Cibin, Giannantonio ; Tomkinson, John ; Parker, Stewart F. ; Valero, Rosendo ; Pedro Lopes, R ; Carvalho, Luís A. E. Batista de | article | openAccess |
| 36 | 2013 | New sustained release of Zidovudine Matrix tablets − cytotoxicity toward Caco-2 cells | Santos, Jucimary V. ; Pina, Maria Eugénia T. ; Marques, M. P. M. ; Carvalho, Luís A. E. Batista de | article | openAccess |
| 37 | 1-Jan-2015 | On the correction of calculated vibrational frequencies for the effects of the counterions — α,ω-diamine dihydrochlorides | Fiuza, S. M. ; Silva, T. M. ; Marques, M. P. M. ; Carvalho, L. A. E. Batista de ; Amado, A. M. | article | openAccess |
| 38 | 13-Jul-2016 | Osteometrics in burned human skeletal remains by neutron and optical vibrational spectroscopy | Marques, M. P. M. ; Gonçalves, D. ; Amarante, A. I. C. ; Makhoul, C. I. ; Parker, S. F. ; Carvalho, L. A. E. Batista de | article | openAccess |
| 39 | 2013 | Polymorphism in Cisplatin Anticancer Drug | Marques, M. Paula M. ; Valero, Rosendo ; Parker, Stewart F. ; Tomkinson, John ; Carvalho, Luís A. E. Batista de | article | openAccess |
| 40 | 2-Oct-2018 | Potential of Bioapatite Hydroxyls for Research on Archeological Burned Bone | Mamede, Adriana P. ; Vassalo, Ana R. ; Piga, Giampaolo ; Cunha, Eugénia ; Parker, Stewart F. ; Marques, M. Paula M. ; Carvalho, Luís A. E. Batista de ; Gonçalves, David | article | restrictedAccess |
| 41 | 2012 | Pt(II) Complexes with Linear Diamines—Part I: Vibrational Study of Pt-Diaminopropane | Carvalho, Ana L. M. Batista de ; Fiuza, Sónia M. ; Tomkinson, John ; Carvalho, Luís A. E. Batista de ; Marques, M. Paula M. | article | openAccess |
| 42 | 1-Jan-2016 | Raman spectroscopic evidence for the inclusion of decanoate ion in trimethyl-β-cyclodextrin | Seiça, Ana Filipa ; Carvalho, Luís A. E. Batista de ; Marques, M. Paula M. ; Dias, José J. C. Teixeira | article | openAccess |
| 43 | 2016 | Rather yield than break: assessing the influence of human bone collagen content on heat-induced warping through vibrational spectroscopy | Vassalo, Ana ; Cunha, Eugénia ; Carvalho, Luís A. E. Batista de ; Gonçalves, David | article | embargoedAccess |
| 44 | Sep-2010 | Relatório de estágio de mestrado em ensino da física e química no 3º ciclo do ensino básico e no ensino secundário | Valongueiro, Vítor Hugo Costa. | masterThesis | openAccess |
| 45 | Sep-2010 | Relatório de Estágio de Mestrado em Ensino da Física e Química no 3ºCiclo do Ensino Básico e no Ensino Secundário | Vicente, Carla Maria Alves Dinis. | masterThesis | openAccess |
| 46 | 1-Jan-2013 | Spectroscopy of Biological Molecules”, Série Advances in Biomedical Spectroscopy | Lopes, R.P. ; Marques, M. P. M. ; Valero, R. ; Tomkinson, J. ; Carvalho, L. A. E. Batista de | bookPart | openAccess |
| 47 | 1-Jan-2013 | “Spectroscopy of Biological Molecules”, Série Advances in Biomedical Spectroscopy, vol. 7 | Carvalho, A. L. M. Batista de ; Fiuza, S. M. ; Tomkinson, J. ; Carvalho, L. A. E. Batista de ; Marques, M. P. M. | bookPart | openAccess |
| 48 | 2018 | Targeting the OH’s within Bone´s Bioapatite by Neutron and Optical Vibrational Spectroscopy | Mamede, A. P. ; Vassalo, A. R. ; Piga, G. ; Cunha, E. ; Parker, S. F. ; Marques, M. P. M. ; Carvalho, L. A. E. Batista de ; Gonçalves, D. | conferenceObject | openAccess |
| 49 | 2012 | The autooxidation process in linoleic acid screened by Raman spectroscopy | Machado, N. F. L. ; Carvalho, L. A. E. Batista de ; Otero, J. C. ; Marques, M. P. M. | article | openAccess |
| 50 | 2018 | Unravelling the mystery: FTIR-ATR and inelastic neutron scattering (INS) spectroscopies applied to the analysis of burned human skeletal remains | Vassalo, A. R. ; Mamede, P. ; Cunha, E. ; Parker, S. F. ; Marques, Maria Paula Matos ; Gonçalves, D. ; Carvalho, L. A. E. Batista de | conferenceObject | openAccess |
| 51 | 1-Jan-2017 | Vibrational and conformational studies of 1,3-diaminopropane and its N-deuterated and N-ionised derivatives | Mendes, Sofia R. O. ; Amado, Ana M. ; Tomkinson, John ; Marques, M. Paula M. ; Carvalho, Luís A. E. Batista de | article | embargoedAccess |
| 52 | 2018 | Widening the frontiers in Forensic Identification: probing burned human bones with neutron techniques | Mamede, A. P. ; Vassalo, A. R. ; Makhoul, C. ; Gonçalves, D. ; Parker, S. F. ; Kockelman, W ; Marques, Maria Paula Matos ; Carvalho, Luís A. E. Batista de | article | openAccess |