Cunha-Oliveira, Teresa
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Credit Name
Cunha-Oliveira, Teresa
Name
Cunha-Oliveira, Teresa
Variants
Oliveira, M.T.
Cunha-Oliveira, T.
Oliveira, T.C.
Cunha-Oliveira, T.
Oliveira, T.C.
Email
teresa.oliveira@uc-biotech.pt
Other emails
https://orcid.org/0000-0002-7382-0339
Scopus Author ID
Researcher ID
Status
UC Researcher
Biography
Teresa Cunha-Oliveira got her PhD in Biology (Cell Biology) in 2007 from the University of Coimbra (Portugal), having contributed to introduce the role of mitochondria in the field of drug addiction, particularly concerning cocaine, heroin and amphetamine. In her first post-doctoral period (2007-2010) in the Center for Neuroscience and Cell Biology (CNC, Coimbra), she collaborated with a Medicinal Chemistry group at the University of Porto to uncover the cellular effects of a newly found chemical interaction between heroin and cocaine (speedball) that could have a great impact in the understanding of poly-drug abuse consequences. In her second post-doctoral period (2010-2012), she was focused on the role of mitochondria in neurodegenerative diseases, including Huntington’s disease (HD) and Parkinson’s disease. She became interested in the epigenetic mechanisms associated with long-term mitochondrial dysfunction and contributed to characterize the bioenergetic dysfunction in cybrids from HD patients, evidencing the involvement of pyruvate dehydrogenase (PDH) and the promising role of epigenetic modulators in reversing PDH and mitochondrial dysfunctions in HD models. From 2013 until now, she is part of the MitoXT group at the CNC, more interested in the role of mitochondria in drug toxicology and experimental therapeutics, especially doxorubicin (DOX), an anticancer agent with long-term cardiotoxic side-effects involving mitochondria. She contributed to describe DOX-induced mitochondrial dysfunction, transcriptional deregulation and epigenetic signalling using in vitro and in vivo models. Her current interests include the development and validation of innovative screening assays to assess mitochondrial health with applications in toxicology, diagnostics and development of innovative therapeutic strategies for personalized medicine.
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Publications
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Fulltext
Results 1-11 of 11 (Search time: 0.021 seconds).
| Issue Date | Title | Author(s) | Type | Access | |
|---|---|---|---|---|---|
| 1 | 2007 | Adaptation to oxidative stress in the chronic effects of cocaine and amphetamine | Cunha-Oliveira, T. ; Rego, A. C. ; Macedo, T. ; Oliveira, C. R. | article | openAccess |
| 2 | 2009 | BDNF regulates BIM expression levels in 3-nitropropionic acid-treated cortical neurons | Almeida, S. ; Laço, M. ; Cunha-Oliveira, T. ; Oliveira, C. R. ; Rego, A. C. | article | openAccess |
| 3 | 2008 | Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs | Cunha-Oliveira, Teresa ; Rego, Ana Cristina ; Oliveira, Catarina R. | article | openAccess |
| 4 | 2005 | Differential cytotoxic responses of PC12 cells chronically exposed to psychostimulants or to hydrogen peroxide | Cunha-Oliveira, T. ; Rego, A. C. ; Morgadinho, M. T. ; Sarmento, A. ; Macedo, T. ; Oliveira, C. R. | conferenceObject | openAccess |
| 5 | 2006 | Differential cytotoxic responses of PC12 cells chronically exposed to psychostimulants or to hydrogen peroxide | Cunha-Oliveira, Teresa ; Rego, A. Cristina ; Morgadinho, Maria Teresa ; Macedo, Tice ; Oliveira, Catarina Resende | article | openAccess |
| 6 | 2009 | Dysregulation of CREB Activation and Histone Acetylation in 3-Nitropropionic Acid-Treated Cortical Neurons: Prevention by BDNF and NGF | Almeida, Sandra ; Cunha-Oliveira, Teresa ; Laço, Mário ; Oliveira, Catarina R. ; Rego, A. Cristina | article | openAccess |
| 7 | 2005 | Heroin-induced degeneration of cortical neurons involves mitochondria-dependent apoptosis | Cunha-Oliveira, T. ; Rego, A. C. ; Macedo, T. ; Oliveira, C. R. | article | openAccess |
| 8 | 2006 | Mitochondrial dysfunction and caspase activation in rat cortical neurons treated with cocaine or amphetamine | Cunha-Oliveira, T. ; Rego, A. C. ; Cardoso, S. M. ; Borges, F. ; Swerdlow, R. ; Macedo, T. ; Oliveira, C. R. | article | openAccess |
| 9 | 7-Nov-2007 | Neuronal dysfunction induced by drugs of abuse | Oliveira, Maria Teresa Martins da Cunha | doctoralThesis | openAccess |
| 10 | 2007 | Street heroin induces mitochondrial dysfunction and apoptosis in rat cortical neurons | Cunha-Oliveira, Teresa ; Rego, A. Cristina ; Garrido, Jorge ; Borges, Fernanda ; Macedo, Tice ; Oliveira, Catarina Resende | article | openAccess |
| 11 | Oct-2006 | Synthesis and Cytotoxic Profile of 3,4-Methylenedioxymethamphetamine (“Ecstasy”) and Its Metabolites on Undifferentiated PC12 Cells: A Putative Structure−Toxicity Relationship | Milhazes, Nuno ; Cunha-Oliveira, Teresa ; Martins, Pedro ; Garrido, Jorge ; Oliveira, Catarina ; Rego, A. Cristina ; Borges, Fernanda | article | openAccess |