Grazina, Manuela M.

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Name
Grazina, Manuela M.
 
Variants
Grazina, M.
 
 
 
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Researcher ID
 
Status
UC Researcher
Biography
Manuela Grazina is specialized in Human Genetics, Biochemical Genetics and Pharmacogenomics, with a major focus in the study of a group of rare diseases, mitochondrial cytopathies, and neuropsychiatric disorders, particularly drug addiction and pain.
She has got her PhD in Biomedical Sciences in the area of Biochemical Genetics (2006), Graduated in Biomedicine (1997), Master in Cell Biology (specialization in Neurogenetics; 2004) and she has a degree in Biochemistry (5 years grade, pre – Bologna, 1991), at the University of Coimbra.
She is member of CNC as Researcher since 1992, and created the Laboratory of Biochemical Genetics (in CNC / FMUC) in 1995, at the University of Coimbra, with development of biochemical and genetic tests as tools for reverse translational research and diagnostics, with a strong component of Services to the community. She is the Head of the Laboratory of Biochemical Genetics, Center for Neuroscience of Coimbra, since March 1995.
She has established several international collaborations aiming to bring new developments to the research group, namely at the Baylor College of Medicine (Houston, USA), University of Newcastle upon Type (UK), Mitochondrial Biology Unit - Medical Research Council (Cambridge , UK) and CICAB Clinical Research Centre Extremadura University Hospital and Medical School, (Badajoz, Spain).
She has settled a study group of Pharmacogenomics Research in 2007, with the goal of identifying complete genetic and metabolic profiles influencing metabolism and toxicity of xenobiotics (eg drugs) and Manuela Grazina is a member of the CEIBA.FP Consortium of the Ibero-American Network of Pharmacogenetics and Pharmacogenomics (RIBEF) since February 2012.
Manuela Grazina coordinates a group of Reverse Translational Research in Mitochondrial Bigenomics and Pharmacogenomics, at the CNC, in close liaison with the Faculty of Medicine, University of Coimbra, since 2008.
She is an Assistant Professor at the Faculty of Medicine, University of Coimbra, where she has been teaching since 1996. Manuela Grazina is also teaching the discipline of Human Genetics in Universities of Évora (since 2010) and Algarve (since 2008), under the scope of cooperation between Universities, and collaborates in teaching with other Universities / Colleges (Faculties of Pharmacy of Lisbon and Coimbra, Institute of Biomedical Sciences Abel Salazar - Porto). Additionally, Manuela Grazina has been dedicated to the Certification of Quality and she is Director of Quality at CNC since 2006.
Manuela Grazina has a strong experience in organizing Advanced Courses (14, since 2010) and has also organized several scientific meetings, workshops and seminars.
She is the co -author of 32 "peer -reviewed" publications, including 4 book chapters and 74 abstracts published in proceedings of scientific meetings (majority indexed and peer-reviewed), as well as 380 scientific communications, 252 of which are posters , 48 conferences by invitation and 80 oral presentations.
Manuela Grazina is responsible for the supervision of 12 PhD theses (1 completed), 32 MSc (26 completed) and 20 monographs (all completed). She has been participating in 17 research funded projects, includes 2 (FCT), in which she is the Principal Investigator.
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Publications

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Type:  masterThesis

Results 1-31 of 31 (Search time: 0.597 seconds).

Issue DateTitleAuthor(s)TypeAccess
12010Abordagem farmacogenómica na doença de Alzheimer : variação genética associada a CYP2D6Martins, Patrícia Andreia Gabriel masterThesisopenAccess
216-Sep-2015Analysis of mitochondrial genome in frontotemporal lobar degeneration: Contribution of RNRs and correlation with the Biochemical PhenotypeTavares, Raquel Inês Fernandes Martins masterThesisopenAccess
32011Análise do gene DGUOK em crianças com síndrome de depleçãoPereira, Carla Isabel Teixeira de Jesus masterThesisopenAccess
42012Análise experimental da patogenicidade de variações de sequência novas no genoma mitocondrialBacalhau, Mafalda Rita Avó masterThesisopenAccess
52009Análise farmacogenómica de efeitos secundários da analgesia epidural com morfina no tratamento da dor pós-cesarianaValentim, Ana do Rosário Caleiro masterThesisopenAccess
62011Antenatal manifestations of mitochondrial disordersTavares, Mariana Silva Vide masterThesisopenAccess
72009Avaliação da actividade enzimática da cadeia respiratória mitocondrial na esclerose múltiplaMendes, Cândida Elsa Frias masterThesisopenAccess
8Feb-2011AZT – Molécula de Morte e Sobrevivência CelularPinto, Catarina Inês Sanches masterThesisopenAccess
92011CD40 in oral squamous cell carcinoma : a posssible role as a new therapeutic targetSoares, Ana Margarida da Rosa masterThesisopenAccess
10Feb-2016Clinical and metabolic characterization of Bronco-Pulmonary Carcinoma in Surgical StadiumDias, José Alberto de Castro e. masterThesisopenAccess
112014Comprehensive analysis of MYOC gene in primary open-angle glaucomaFerreira, Ana Filipa Bento masterThesisopenAccess
122014CYP2D6 genetic variation and predicted metabolic profile in post-cesarean section pain: pharmacogenetic interpretationQuinta, Rosa Margarida FigueiredomasterThesisopenAccess
132016Deficiência das enzimas do ciclo de KrebsSilva, Jaquelina Henriques masterThesisopenAccess
142010Estudo farmacogenético da acção do propofol no sistema energético mitocondrial em células helaLapa, Teresa Alexandra Santos Carvalho masterThesisopenAccess
152011Farmacogenomics and painEufrásio, Ana Isabel Osório masterThesisopenAccess
162016Functional Investigation of OXPHOS assembly factors in Leber’s Hereditary Optic NeuropathyFonseca, Maria Inês Arêlo Manso da masterThesisembargoedAccess
172014Genotype-phenotype correlation in mitochondrial depletion syndrome due to DGUOK deficiencyDuarte, Sara Filipa Rosa masterThesisopenAccess
182015Insights on attentional processing : magic as a new method of researchGonçalves, Diana Pinto masterThesisopenAccess
192012Investigação do cross-talk genómico na neuropatia ótica hereditária de LeberSousa, Tânia Sofia Silva masterThesisopenAccess
202011Investigação do gene TWINKLE em casos de deleções múltiplas do mtDNABaptista, Vera Lúcia da Silva masterThesisopenAccess
212012Investigação do mtDNA nas doenças de Huntington e ParkinsonFernandes, Sabrina masterThesisopenAccess
222012Investigação dos genes MT-CO na demência frontotemporalMartins, Catarina Isabel Mendes masterThesisopenAccess
2312-Sep-2018Investigation of genes associated to mitochondrial import and post-translational processing in LHONTeixeira, Márcia Joana Nascimento masterThesisembargoedAccess
242013Investigation of plasma ATP levels in frontotemporal lobar degenerationMonteiro, Ana RitamasterThesisopenAccess
256-Jun-2017Mitochondrial DNA mutations and Hearing Loss ConnectionAugusto, Paulo José Pina Barreto masterThesisclosedAccess
26May-2013Mitochondrial DNA variants in complex V coding genes contributing to frontotemporal lobar degerationAbrantes, João Paulo Fernandes masterThesisopenAccess
272013Mitochondrial genome analysis in frontotemporal lobar degeneration : tRNAs contributionOliveira, Isabel Maria Isabel Maria Lopes de Matos masterThesisopenAccess
282014MT-CYB sequencing analysis in frontotemporal lobar degenerationGonçalves, Mónica Silveira masterThesisopenAccess
292014Pharmacogenomics of drug addictionMacedo, Carolina Augusta Azevedo Ferreira demasterThesisopenAccess
302014(Re)defining the concept of "pathogenic mutation" : translational analysis of an unusual lhon caseGuiomar, Pedro Filipe Rebelo masterThesisopenAccess
312011Variação genética do gene CYPD6 na analgesia do parto : abordagem farmacogenómicaRaposo, Ana Cristina Baptista masterThesisopenAccess