Foie Gras: Bioenergetic Remodeling in the Pathophysiology and Treatment of Non-Alcoholic Fatty Liver Disease

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Primary Data

Project title
Foie Gras: Bioenergetic Remodeling in the Pathophysiology and Treatment of Non-Alcoholic Fatty Liver Disease
Code
info:eu-repo/grantAgreement/EC/H2020/722619/EU
Project Coordinator
Organization
 
Status
Closed
Start date
01-01-2017
Expected Completion
30-06-2021
 
Co-Investigator(s)

Description

Abstract
Objective: FOIE GRAS provides innovative training for 13 early stage researchers (ESRs) to answer two critical and unanswered questions: a) Is hepatic bioenergetic remodelling involved in NAFLD pathogenesis, and target for stratification or therapeutic/lifestyle interventions? and b) Is the disruption of the gut-liver axis involved in NAFLD progression? In Western Societies, there has been a recent surge of non-alcoholic fatty liver disease (NAFLD). Its progression to nonalcoholic steatohepatitis (NASH) is a leading risk factor for development of Type 2 diabetes, cirrhosis, and hepatocellular carcinoma. FOIE GRAS is first in supporting a cohesive and synergistic intersection of complementary and interdisciplinary training skills from academic and non-academic partners. FOIE GRAS combines strong scientific expertise with integrated and complementary training in translational research, clinical practice, technology commercialization, and public outreach, the combination of which in targeting NAFLD is lacking in the EU. Industrial partners CETICS, Mediagnost and Seahorse Biosciences provide experience on technology commercialization alongside scientific contributions while the affiliated patient organization will contribute with important training in societal awareness topics. ESRs training will utilize network-wide workshops and secondments to foster translation of basic research to clinical applications and SME creation. This diverse yet integrated skill set enhances the employment prospects of the trained researchers in both academic and non-academic sectors. Researchers will be endowed with excellent basic scientific knowledge and timely technology transfer know-how for developing novel therapeutic approaches for reversing the burden of NAFLD, thereby advancing both health and economic well-being of European citizens and approaching NAFLD research in the EU from its counterparts in the US and Asia.
 
Keyword(s)
Medical and health sciences
Basic medicine
Pharmacology and pharmacy
Drug discovery
Pathology
Nutrition
Oncology
Liver cancer
Clinical medicine
Hepathology

Publications
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Type:  doctoralThesis

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Issue DateTitleAuthor(s)TypeAccess
18-Oct-2021“A Healthy Liver Will Always Deliver” : Development of a Comic to Raise Awareness About Non-Alcoholic Fatty Liver Disease (NAFLD) and Other Metabolic DisordersAlemany i Pagès, MireiadoctoralThesisembargoedAccess