This work was financed by FEDER - Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020 - Operational Programme for Competitiveness and Internationalisation (POCI), Portugal 2020, and by Portuguese funds through FCT - Fundação para a Ciência e a Tecnologia/ Ministério da Ciência, Tecnologia e Inovação in the framework of the projects "Institute for Research 15 and Innovation in Health Sciences" (POCI-01-0145-FEDER-007274 to BS); EC (ERC project nº 307384, “Nanotrigger” and ERA-Chair project nº 669088, ERA@UC, both to LF). SP, MHM and CR would like to thank to Fundação para a Ciência e a Tecnologia (FCT), Portugal, for financial support (SFRH/BPD/96048/2013; SFRH/BD/131587/2017; SFRH/BD/52337/2013).

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This work was financed by FEDER - Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020 - Operational Programme for Competitiveness and Internationalisation (POCI), Portugal 2020, and by Portuguese funds through FCT - Fundação para a Ciência e a Tecnologia/ Ministério da Ciência, Tecnologia e Inovação in the framework of the projects "Institute for Research 15 and Innovation in Health Sciences" (POCI-01-0145-FEDER-007274 to BS); EC (ERC project nº 307384, “Nanotrigger” and ERA-Chair project nº 669088, ERA@UC, both to LF). SP, MHM and CR would like to thank to Fundação para a Ciência e a Tecnologia (FCT), Portugal, for financial support (SFRH/BPD/96048/2013; SFRH/BD/131587/2017; SFRH/BD/52337/2013).